E-Book Overview
Volume 4 of this series is addressed primarily at practitioners in the field who seek a quick overview of the synthetic routes which have been used to access specific classes of therapeutic agents. This volume covers the chemistry of those compounds which have been granted a United States Adopted Name (USAN) in the five years between 1983 and 1987. Many examples of actual applications of chemistry are provided by this book, which presumes a good working knowledge of chemical synthesis and at least a passing acquaintance with biology and pharmacology.
E-Book Content
THE ORGANIC OF DRUG
CHEMISTRY
SYNTHESIS
VOLUME 4
DANIEL LEDNICER National Cancer Institute Bethesda, Maryland LESTER A. MITSCHER Department of Medicinal Chemistry The University of Kansas Lawrence, Kansas with GUNDA I. GEORG Department of Medicinal Chemistry The University of Kansas Lawrence, Kansas
A Wiley-Interscience Publication John Wiley & Sons, Inc. New York / Chichester / Brisbane / Toronto / Singapore
Copyright © 1990 by John Wiley & Sons, Inc. All rights reserved. Published simultaneously in Canada. Reproduction or translation of any part of this work beyond that permitted by Section 107 or 108 of the 1976 United States Copyright Act without the permission of the copyright owner is unlawful. Requests for permission or further information should be addressed to the Permissions Department, John Wiley & Sons, Inc. Library of Congress Cataloging in Publication Data: (Revised for volume 4) Lednicer, Daniel, 1929The organic chemistry of drug synthesis. "A Wiley-Interscience publication." Includes bibliographical references and Index. 1. Chemistry, Pharmaceutical. 2. Drugs. 3. Chemistry, Organic-Synthesis. I. Mitscher, Lester A., joint author. II. Title. [DNLM 1. Chemistry, Organic. 2. Chemistry, Pharmaceutical. 3. Drugs-Chemical synthesis. QV 744 L473o 1977