E-Book Overview
Recent progress has led to a better understanding of the molecular structure of sodium channels, how they work and the mechanisms that restrict their expression to particular cell types.This book explains how these channels are modulated in various pathological states to enable the development of therapeutic strategies based on sodium channel restoration.The authors present the most current research on sodium channels andneuronal function. * Brings together both the basic biology and biophysics with detailed consideration of the medical applications in chronic pain and epilepsy. * Includes coverage of channelopathies, sodium channel gene expression, the modulation of sodium channels, and molecular mechanisms of gating and drug block of sodium channels.
E-Book Content
Sodium Channels and Neuronal Hyperexcitability. Novartis 241 Copyright & 2002 John Wiley & Sons Ltd Print ISBN 0-471-48530-6 Online ISBN 0-470-84668-2
SODIUM CHANNELS AND NEURONAL HYPEREXCITABILITY
Sodium Channels and Neuronal Hyperexcitability. Novartis 241 Copyright & 2002 John Wiley & Sons Ltd Print ISBN 0-471-48530-6 Online ISBN 0-470-84668-2
The Novartis Foundation is an international scienti¢c and educational charity (UK Registered Charity No. 313574). Known until September 1997 as the Ciba Foundation, it was established in 1947 by the CIBA company of Basle, which merged with Sandoz in 1996, to form Novartis. The Foundation operates independently in London under English trust law. It was formally opened on 22 June 1949. The Foundation promotes the study and general knowledge of science and in particular encourages international co-operation in scienti¢c research. To this end, it organizes internationally acclaimed meetings (typically eight symposia and allied open meetings and 15^20 discussion meetings each year) and publishes eight books per year featuring the presented papers