E-Book Content
THE
PEPTIDES
Analysis, S y n t h e s i s , Biology Treatise
Editors
S . U D E N F R I E N D A N D J. MEIENHOFER Volume 1 Major M e t h o d s of Peptide Bond F o r m a t i o n Volume 2 Special M e t h o d s in Peptide Synthesis, Part A Volume 3 P r o t e c t i o n of F u n c t i o n a l G r o u p s in Peptide Synthesis Volume 4 M o d e r n T e c h n i q u e s of Conformational, Structural, and Configurational Analysis Volume 5 Special M e t h o d s in Peptide Synthesis, Part B Volume 6 Opioid Peptides: Biology, Chemistry, and Genetics Volume 7 Edited by Victor J. Hruby Conformation in Biology and Drug Design
The Peptides Analysis, Synthesis, Biology Edited
by
SIDNEY UDENFRIEND
JOHANNES MEIENHOFER
Roche Institute of Molecular Biology Nutley, New Jersey
Hoffmann-La Roche Inc. Nutley, New Jersey
VOLUME 7
Conformation in Biology and Drug Design Edited
by
VICTOR J. HRUBY Department of Chemistry University of Arizona Tucson, Arizona
1985
ACADEMIC PRESS, INC. Harcourt Brace Jovanovich, Publishers
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DATA
Main entry under title: The Peptides : analysis, synthesis, biology. Vol. edited by Sidney Udenfriend, Johannes Meienhofer. Includes bibliographies and indexes. Contents: v. 1. Major methods of peptide bond formation.—v. 2 Special methods in peptide synthesis, part A. —[etc.]—v. 7. Conformation in biology and drug design. 1. Peptides — Collected works. I. Gross, Erhard. II. Meienhofer, Johannes. [DNLM: 1. Peptides. QU 68 P424] QP552.P4P47 574.1'92456 78-31958 ISBN 0-12-304207-0 (v. 7)
PRINTED IN THE UNITED STATES OF AMERICA
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Contributors
Numbers in parentheses indicate the pages on which the authors' contributions begin.
Wolfgang Bermel (437), Institute of Organic C h e m i s t r y , J. W. G o e t h e U n i v e r s i t y , D-6000 Frankfurt-50, F e d e r a l Republic of G e r m a n y Michael Blumenstein* (355), D e p a r t m e n t of Biochemistry and P h a r m a cology, Tufts U n i v e r s i t y School of Medicine, B o s t o n , M a s s a c h u s e t t s 02111 Lila M. Gierasch (405), D e p a r t m e n t of C h e m i s t r y , University of Dela w a r e , N e w a r k , D e l a w a r e 19716 Jerry D. Glickson (301), D e p a r t m e n t of Radiology, T h e J o h n s H o p k i n s School of M e d i c i n e , B a l t i m o r e , M a r y l a n d 21205 A . T. Hagler (213), A g o u r o n Institute, L a Jolla, California 92037 Victor J. Hruby (1), D e p a r t m e n t of C h e m i s t r y , University of A r i z o n a , T u c s o n , A r i z o n a 85721 Horst Kessler (437), Institute of Organic C h e m i s t r y , J. W. G o e t h e Univer sity, D-6000 Frankfurt-50, F e d e r a l Republic of G e r m a n y Robert E. Lenkinski (301), D e p a r t m e n t of C h e m i s t r y , University of G u e l p h , G u e l p h , O n t a r i o , C a n a d a N I G 2W1 Arndt Mtiller (437), Institute of Organic C h e m i s t r y , J. W. G o e t h e Univer sity, D-6000 Frankfurt-50, F e d e r a l Republic of G e r m a n y Stanley J. Opell