Pesticide Chemistry–3. Third International Congress Of Pesticide Chemistry Including The Symposium On Dispersion Dynamics Of Pollutants In The Environment

INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY APPLIED CHEMISTRY DIVISION PESTICIDE CHEMISTRY-3 Selected specially invited lectures presented at the T H I R D INTERNATIONAL CONGRESS O F PESTICIDE CHEMISTRY INCLUDING THE SYMPOSIUM ON DISPERSION D Y N A M I C S O F POLLUTANTS IN T H E E N V I R O N M E N T held at Helsinki, Finland 3-9 July 1974 Symposium Editor P. VARO University of Helsinki LONDON BUTTERWORTHS ENGLAND : B U T T E R W O R T H & CO. (PUBLISHERS) LTD. L O N D O N : 88 Kingsway, W C 2 B 6AB AUSTRALIA. B U T T E R W O R T H S PTY. LTD. S Y D N E Y : 586 Pacific Highway, N S W 2067 Also at iMelbourne, Brisbane, Adelaide and Perth CANADA: B U T T E R W O R T H & CO. (CANADA) LTD. T O R O N T O : 2265 Midland Avenue, Scarborough, O n t a r i o , M I P 4SI NEW ZEALAND: BUTTERWORTHS O F NEW ZEALAND LTD. W E L L I N G T O N : 26-38 W a r i n g Taylor Street, 1 SOUTH AFRICA: B U T T E R W O R T H & C O . ( S O U T H A F R I C A ) (PTY.) L T D . D U R B A N : 152-154 Gale Street All rights reserved. N o part of this publication may be reproduced or transmitted in any form or by any means, including photocopying and recording, without the written permission of the copyright holder, application for which should be addressed to the publisher. Such written permission must also be obtained before any part of this publication is stored in a retrieval system of any nature. The contents of this book appear in Pure and Applied Chemistry, Vol. 42, Nos. 1-2 (1975) International U n i o n of Pure and Applied Chemistry 1975 I S B N 0 408 70708 9 Printed in G r e a t Britain by Page Bros (Norwich) Ltd, N o r w i c h CONGRESS SCIENTIFIC PROGRAMME COMMITTEE Chairman : P . KOIVISTOINEN Members : M . ISOTALO Y . PESSI M . MARKKULA K . SALMINEN V . MATTINEN P. SUMARI H . WESTERMARCK Associate Members: A . AAPOLA J. RAUTAPÄÄ T . PEKKANEN M . TOI VIAINEN Secretary: SYMPOSIUM J. KOIVURINTA SCIENTIFIC PROGRAMME COMMITTEE M . J. KARVONEN Chairman: Members : I. KANGAS A . LAAMANEN P . KOIVISTOINEN J. LARINKARI F . KORTE A . VOIPIO Secretaries : W . KLEIN P . VARO VI CONGRESS SCIENTIFIC PROGRAMME COMMITTEE Chairman : P . KOIVISTOINEN Members : M . ISOTALO Y . PESSI M . MARKKULA K . SALMINEN V . MATTINEN P. SUMARI H . WESTERMARCK Associate Members: A . AAPOLA J. RAUTAPÄÄ T . PEKKANEN M . TOI VIAINEN Secretary: SYMPOSIUM J. KOIVURINTA SCIENTIFIC PROGRAMME COMMITTEE M . J. KARVONEN Chairman: Members : I. KANGAS A . LAAMANEN P . KOIVISTOINEN J. LARINKARI F . KORTE A . VOIPIO Secretaries : W . KLEIN P . VARO VI THE DESIGN OF ANTICHOLINESTERASES R . D . O'BRIEN Section of Neurobiology and Behavior, Cornell University, New York, NY 14850, USA Ithaca, ABSTRACT The significance of new findings in two areas will be discussed with respect to the design of inhibitors of acetylcholinesterase. One area is that of enzyme structure, including the oligomeric form and the existence of allosteric binding sites, of isozymes and of a mutant enzyme. The other area is that of the forces which bind inhibitors to the enzyme prior to reacting with it, including ionic, hydrophob