E-Book Overview
This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.
E-Book Content
Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention
Cancer Metastasis – Biology and Treatment VOLUME 1
Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention Edited by
Wen G. Jiang University of Wales College of Medicine and
Robert E. Mansel University of Wales College of Medicine
KLUWER ACADEMIC PUBLISHERS NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW
eBook ISBN: Print ISBN:
0-306-48388-2 0-7923-6395-7
©2004 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow Print ©2000 Kluwer Academic Publishers Dordrecht All rights reserved
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Contents
Contributors Metastatic Cascade, Molecular/Cellular Events and New Therapeutic Opportunities
vii
1
WEN G. JIANG AND ROBERT E. MANSEL
The Role of Integrin-Mediated Processes in the Biology of Metastasis JOHN F MARSHALL AND DAWN DAVIES The Role of Hyaluronan and Its Degradation Products in Tumour Angiogenesis and Metastasis
19
55
DAVID C. WEST
The E-Cadherin/Catenin Complex in Invasion: The Role of Ectodomain Shedding VEERLE NOË, ERIK BRUYNEEL, MARC MAREEL AND MARC BRACKE Cancer And Cancer Metastasis-Related Genes STEVE HISCOX Hepatocyte Growth Factor and Met in Tumour Invasion-Metastasis: From Mechanisms to Cancer Prevention KUNIO MATSUMOTO AND TOSHIKAZU NAKAMURA
73
121
143
vi
Contents
Tight Junctions, A Critical Structure in the Control of Cancer Invasion 195 and Metastasis WEN G. JIANG, TRACEY MARTIN, IRAJ LLAFFAFIAN, ROBERT E. MANSEL Bone Marrow Micrometastases Detection and Significance HEMANT SINGHAL AND MICHAEL P. OSBORNE Polyunsaturated Fatty Acids and Their Role in Cancer Invasion and Metastasis WEN G JIANG, AMANDA REDFERN, ALDO EYNARD AND ROBERT E MANSEL
215
225
Metastatic Endocrine Cancer GREGORY P SADLER AND MALCOLM H WHEELER
251
Prostate Cancer MALCOLM D MASON
279
Gastrointestinal Tumours: Cancer Metastasis, Molecular and Cellular 297 Biology L J FON AND P D CAREY Breast Cancer Metastasis NADER KHONJI, DAYALAN CLARKE, ROBERT E MANSEL
339
The Malignant Lymphomas CHRISTOPHER H. POYNTON
353
Cancer Metastasis: Biological and Clinical Aspects, Gynaecological Cancer MALCOLM ADAMS AND BARAT JASANI
381
Index
421
Contributors
Adam, Malcolm D. Velindre NHS Health Care Trust, Whitchurch, Cardiff CF14 2TL, The United Kingdom Bracke, Marc. Laboratory of Experimental Cancerology, University Hospital of Gent, UZG, B-9000 Ghent, Belgium Bruyneel, Erik. Laboratory of Experimental Cancerology, University Hospital of Gent, UZG, B-9000 Ghent, Belgium Carey, P. D. Surgical Unit, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, The United Kingdom Clarke, Dayalan. University Department of Surgery, University of W