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This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.
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Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention Cancer Metastasis – Biology and Treatment VOLUME 1 Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention Edited by Wen G. Jiang University of Wales College of Medicine and Robert E. Mansel University of Wales College of Medicine KLUWER ACADEMIC PUBLISHERS NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW eBook ISBN: Print ISBN: 0-306-48388-2 0-7923-6395-7 ©2004 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow Print ©2000 Kluwer Academic Publishers Dordrecht All rights reserved No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at: and Kluwer's eBookstore at: http://kluweronline.com http://ebooks.kluweronline.com Contents Contributors Metastatic Cascade, Molecular/Cellular Events and New Therapeutic Opportunities vii 1 WEN G. JIANG AND ROBERT E. MANSEL The Role of Integrin-Mediated Processes in the Biology of Metastasis JOHN F MARSHALL AND DAWN DAVIES The Role of Hyaluronan and Its Degradation Products in Tumour Angiogenesis and Metastasis 19 55 DAVID C. WEST The E-Cadherin/Catenin Complex in Invasion: The Role of Ectodomain Shedding VEERLE NOË, ERIK BRUYNEEL, MARC MAREEL AND MARC BRACKE Cancer And Cancer Metastasis-Related Genes STEVE HISCOX Hepatocyte Growth Factor and Met in Tumour Invasion-Metastasis: From Mechanisms to Cancer Prevention KUNIO MATSUMOTO AND TOSHIKAZU NAKAMURA 73 121 143 vi Contents Tight Junctions, A Critical Structure in the Control of Cancer Invasion 195 and Metastasis WEN G. JIANG, TRACEY MARTIN, IRAJ LLAFFAFIAN, ROBERT E. MANSEL Bone Marrow Micrometastases Detection and Significance HEMANT SINGHAL AND MICHAEL P. OSBORNE Polyunsaturated Fatty Acids and Their Role in Cancer Invasion and Metastasis WEN G JIANG, AMANDA REDFERN, ALDO EYNARD AND ROBERT E MANSEL 215 225 Metastatic Endocrine Cancer GREGORY P SADLER AND MALCOLM H WHEELER 251 Prostate Cancer MALCOLM D MASON 279 Gastrointestinal Tumours: Cancer Metastasis, Molecular and Cellular 297 Biology L J FON AND P D CAREY Breast Cancer Metastasis NADER KHONJI, DAYALAN CLARKE, ROBERT E MANSEL 339 The Malignant Lymphomas CHRISTOPHER H. POYNTON 353 Cancer Metastasis: Biological and Clinical Aspects, Gynaecological Cancer MALCOLM ADAMS AND BARAT JASANI 381 Index 421 Contributors Adam, Malcolm D. Velindre NHS Health Care Trust, Whitchurch, Cardiff CF14 2TL, The United Kingdom Bracke, Marc. Laboratory of Experimental Cancerology, University Hospital of Gent, UZG, B-9000 Ghent, Belgium Bruyneel, Erik. Laboratory of Experimental Cancerology, University Hospital of Gent, UZG, B-9000 Ghent, Belgium Carey, P. D. Surgical Unit, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, The United Kingdom Clarke, Dayalan. University Department of Surgery, University of W