Deutsche Forschungsgemeinschaft Microbial Fundamentals of Biotechnology
Microbial Fundamentals of Biotechnology. DFG, Deutsche Forschungsgemeinschaft Copyright © 2001 WILEY-VCH Verlag GmbH, Weinheim ISBN: 3-527-30615-3
Deutsche Forschungsgemeinschaft
Microbial Fundamentals of Biotechnology Final report of the collaborative research centre 323, „Mikrobielle Grundlagen der Biotechnologie: Struktur, Biosynthese und Wirkung mikrobieller Stoffe“, 1986 – 1999 Edited by Volkmar Braun and Friedrich Götz Collaborative Research Centres
Deutsche Forschungsgemeinschaft Kennedyallee 40, D-53175 Bonn, Federal Republic of Germany Postal address: D-53175 Bonn Phone: ++49/228/885-1 Telefax: ++49/228/885-2777 E-Mail: (X.400): S = postmaster, P = dfg, A = d400, C = de E-Mail (Internet RFC 822):
[email protected] Internet: http://www.dfg.de
This book was carefully produced. Nevertheless, editor, authors and publisher do not warrant the information contained therein to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate.
Cover: Crystal structure of E.coli FhuA with bound rifamycin CGP 4832 as determined by Ferguson et al. Structure 9:707-16 (2001)
Library of Congress Card No.: applied for
A catalogue record for this book is available from the British Library.
Die Deutsche Bibliothek ± CIP Cataloguing-in-Publication Data A catalogue record for this publication is available from Die Deutsche Bibliothek ISBN 3-527-30615-3
WILEY-VCH Verlag GmbH, Weinheim (Federal Republic of Germany), 2001 Printed on acid-free and chlorine-free paper. All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form ± by photoprinting, microfilm, or any other means ± nor transmitted or translated into a machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law. Composition: ProSatz Unger, Weinheim Printing: betz-druck gmbh, Darmstadt Bookbindung: J. Schåffer GmbH & Co. KG, Grçnstadt Printed in the Federal Republic of Germany
Contents
Antibiotics and Other Biologically Active Microbial Metabolites 1
1.1 1.2 1.3 1.4 1.5 1.6 2 2.1 2.2 2.3
3 3.1 3.2 3.3 3.4 3.5 3.6 3.7
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Volkmar Braun and Friedrich Götz Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Antibiotic research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The unique features of microbial iron transport . . . . . . . . . . . . . . . . Transport of bacterial proteins . . . . . . .