Cover photo credit: Hewison, M. Vitamin D and innate and adaptive immunity. Vitamins and Hormones (2011) 86, pp. 23-62. Academic Press is an imprint of Elsevier 32 Jamestown Road, London, NW1 7BY, UK Radarweg 29, PO Box 211, 1000 AE Amsterdam, The Netherlands Linacre House, Jordan Hill, Oxford OX2 8DP, UK 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA First edition 2011 Copyright # 2011 Elsevier Inc. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone (+44) (0) 1865 843830; fax (+44) (0) 1865 853333; email:
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Former Editors
ROBERT S. HARRIS
KENNETH V. THIMANN
Newton, Massachusetts
University of California Santa Cruz, California
JOHN A. LORRAINE University of Edinburgh Edinburgh, Scotland
PAUL L. MUNSON University of North Carolina Chapel Hill, North Carolina
JOHN GLOVER University of Liverpool Liverpool, England
GERALD D. AURBACH Metabolic Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda, Maryland
IRA G. WOOL University of Chicago Chicago, Illinois
EGON DICZFALUSY Karolinska Sjukhuset Stockholm, Sweden
ROBERT OLSEN School of Medicine State University of New York at Stony Brook Stony Brook, New York
DONALD B. MCCORMICK Department of Biochemistry Emory University School of Medicine, Atlanta, Georgia
Copyright Pages iv-v Contributors Pages xiii-xvi Preface Pages xvii-xviii Gerald Litwack Chapter one - Vitamin D Regulation of Immune Function Pages 1-21 Daniel D. Bikle Chapter two - Vitamin D and Innate and Adaptive Immunity Pages 23-62 Martin Hewison Chapter three - Dendritic Cells Modified by Vitamin D: Future Immunotherapy for Autoimmune Diseases Pages 63-82 Ayako Wakatsuki Pedersen, Mogens Helweg Claesson, Mai-Britt Zocca Chapter four - Retinoic Acid, Immunity, and Inflammation Pages 83-101 Chang H. Kim Chapter five - Vitamin A and Retinoic Acid in the Regulation of B-Cell Development and Antibody Production Pages 103-126 A. Catharine Ross, Qiuyan Chen, Yifan Ma Chapter Six - Retinoic Acid Production by Intestinal Dendritic Cells Pages 127-152 Makoto Iwata, Aya Yokota Chapter seven - Immune Regulator Vitamin A and T Cell Death Pages 153-178 Nikolai Engedal Chapter eight - Vitamin E and Immunity Pages 179-215 Didem Pekmezci Chapter Nine - Vitamin D Effects on Lung Immunity and Respiratory Diseases Pages 217-237 Sif Hansdottir, Martha M. Monick Chapter Ten - Maternal Vitamin D During Pregnancy and Its Relation to Immune-Mediated Diseases in the Offspring Pages 239-260 M.