Development Of Dopaminergic Neurons (neuroscience Intelligence Unit)

NEUROSCIENCE I N T E L L I G E N C E U N I T 4 Umberto di Porzio Roberto Pernas-Alonso Carla Perrone-Capano Development of Dopaminergic Neurons R.G. LANDES C O M P A N Y NEUROSCIENCE INTELLIGENCE UNIT 4 Development of Dopaminergic Neurons Umberto di Porzio, Ph.D., M.D. International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche Naples, Italy Roberto Pernas-Alonso, Ph.D. International Institute of Genetics and Biophysics Consiglio Nazionale delle Ricerche Naples, Italy Carla Perrone-Capano, Ph.D. Faculty of Pharmacy University of Catantaro "Magna Grecie" Roccelletta di Biorgia (cz), Italy R.G. LANDES COMPANY AUSTIN, TEXAS U.S.A. NEUROSCIENCE INTELLIGENCE UNIT Development of Dopaminergic Neurons R.G. LANDES COMPANY Austin, Texas, U.S.A. Copyright © 1999 R.G. Landes Company All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Printed in the U.S.A. Please address all inquiries to the Publishers: R.G. Landes Company, 810 South Church Street, Georgetown, Texas, U.S.A. 78626 Phone: 512/ 863 7762; FAX: 512/ 863 0081 ISBN:1-57059-565-8 While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Library of Congress Cataloging-in-Publication Data Development of Dopaminergic Neurons/ [edited by] Umberto di Porzio, Roberto Pernas-Alonso, and Carla Perrone-Capano p. cm. -- (Neuroscience intelligence unit) Includes biographical references and index ISBN 1-57059-565-8(alk. paper) 1. Development neurobiology. 2. Neurons -- Growth. 3. Dopaminergic mechanism. 4. Dopamine -- Physiological effect. I. Di Porzio, Umberto. II. Pernas-Alonso, Roberto. III. Perrone-Capano, Carla. IV. Series. [DNLM: 1. Neurons --physiology. 2. Dopamine --physiology 3. Biogenic Amine Neurotransmitters--physiology. WL 102.5 D4895 1999] QP363.5.D4726 1999 573.8'536--dc21 DNLM/DLC 95-52676 for Library of Congress CIP CONTENTS 1. Specification and Patterning of the Rostral Neural Tube ....................... 1 Salvador Martinez and Antonio Simeone CNS Axial Patterning and Retinoic Acid ............................................... 2 Early Neural Plate Specification .............................................................. 3 Patterning Mechanisms in the Neural Plate .......................................... 4 Induction of Longitudinal Domains ...................................................... 4 Induction of Transversal Domains ......................................................... 6 Development of Regional Organizers .................................................... 7 Different Histogenetic Competence ....................................................... 7 Local Patterning Centers in Further Defining the Organization of the Forebrain ................................................................................... 8 2. Specification of Dopaminergic Neurons: Inductive Factors and Their Receptors ................................................................................ 15 Mary Hynes and Arnon Rosenthal Induction Along the D-V Axis .............................................................. 16 Induction of a