Yearbook Of Intensive Care And Emergency Medicine Annual Volumes 2006 (yearbook Of Intensive Care And Emergency Medicine)

Yearbook of Intensive Care and Emergency Medicine 2006 Edited by J.-L. Vincent With 160 Figures and 62 Tables 12 Prof. Jean-Louis Vincent Head, Department of Intensive Care Erasme Hospital, Free University of Brussels Route de Lennik 808, B-1070 Brussels, Belgium ISBN 3-540-30155-0 Springer-Verlag Berlin Heidelberg New York ISBN 978-3-540-30155-4 Springer-Verlag Berlin Heidelberg New York ISSN 0942-5381 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com ° Springer-Verlag Berlin Heidelberg 2006 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about the application of operative techniques and medications contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: K + V Fotosatz, Beerfelden Printing: Strauss Offsetdruck, Mærlenbach SPIN 11584445 21/3130-5 4 3 2 1 0 ± Printed on acid-free paper Table of Contents Cellular Responses in Sepsis The Role of Toll-like Receptors in Sepsis . . . . . . . . . . . . . . . W. J. Wiersinga and T. van der Poll 3 The Emerging Role of RAGE in Sepsis . . . . . . . . . . . . . . . . . M. A. Weigand, C. Bopp, and B. W. Bættiger 14 Oxidative Stress in Sepsis: Implications on Liver Protein Patterns and Analysis via Modified Proteomics Technology . . J. A. Vogt, P. Radermacher, and E. Barth HSP90: The Unsung Villain of Sepsis? . . . . . . . . . . . . . . . . . J. P. Burnie and R. C. Matthews 23 35 The Role of Extracellular Heat Shock Proteins in Cellular Inflammation and Injury . . . . . . . . . . . . . . . . . . D. S. Wheeler, B. Zingarelli, and H. R. Wong 45 Quantitative in vivo Protein Synthesis as a Measure of Immune Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A. Januszkiewicz, O. Rooyackers, and J. Wernerman 52 Fluid Resuscitation and Immunomodulation in the Critically Ill . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . M. Raghavan, H. Murray, and J. A. Kellum 68 Cellular Dysfunction Mitochondrial Dysfunction and Critical Illness Myopathy . . . E. Kothmann and S. V. Baudouin 79 Lactic Acidosis and Hyperlactatemia . . . . . . . . . . . . . . . . . . B. Levy 88 VI Table of Contents Cardiovascular Dysfunction Physiology and Pathophysiology of the Natriuretic Peptide System . . . . . . . . . . . . . . . . . . . . . 101 J. Boldt and S. W. Suttner Heart Failure as a Co-Morbid