E-Book Overview
The unraveling of the biology and disease mechanisms of the parathyroid has taken great strides in the recent few years. Parathyroid molecular biology is the first book to describe recent studies and discoveries in the field in detail. Key topics addressed include: The study of the molecular biology of the parathyroid hormone gene and its regulation by calcium, phosphate, and vitamin D The generation of mice with genetic deletions of the parathyroid, as well as mice which fail to develop the parathyroid gland The parathyroid’s connection to the calcium receptor and its effects, such as regulation of PTH secretion, gene expression, and proliferation The genetic mutations leading to diseases of decreased or excessive activity of the parathyroid The mechanisms of actions associated with patients with chronic renal failure and the development of markedly excessive activity of the parathyroid that causes severe bone disease This book will be essential reading to everyone interested in the latest developments in this burgeoning field.
E-Book Content
MOLECULAR BIOLOGY INTELLIGENCE UNIT
NAVEH-MANY MBIU
Tally Naveh-Many
Molecular Biology of the Parathyroid
Molecular Biology of the Parathyroid
MOLECULAR BIOLOGY INTELLIGENCE UNIT
Molecular Biology of the Parathyroid Tally Naveh-Many, Ph.D. Minerva Center for Calcium and Bone Metabolism Nephrology Services Hadassah Hebrew University Medical Center Jerusalem, Israel
LANDES BIOSCIENCE / EUREKAH.COM GEORGETOWN, TEXAS U.S.A.
KLUWER ACADEMIC / PLENUM PUBLISHERS NEW YORK, NEW YORK U.S.A.
MOLECULAR BIOLOGY OF THE PARATHYROID Molecular Biology Intelligence Unit Landes Bioscience / Eurekah.com Kluwer Academic / Plenum Publishers Copyright ©2005 Eurekah.com and Kluwer Academic / Plenum Publishers All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system; for exclusive use by the Purchaser of the work. Printed in the U.S.A. Kluwer Academic / Plenum Publishers, 233 Spring Street, New York, New York, U.S.A. 10013 http://www.wkap.nl/ Please address all inquiries to the Publishers: Landes Bioscience / Eurekah.com, 810 South Church Street Georgetown, Texas, U.S.A. 78626 Phone: 512/ 863 7762; FAX: 512/ 863 0081 www.Eurekah.com www.landesbioscience.com Molecular Biology of the Parathyroid, edited by Tally Naveh-Many, Landes / Kluwer dual imprint / Landes series: Molecular Biology Intelligence Unit ISBN: 0-306-47847-1 While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein.
Library of Congress Cataloging-in-Publication Data Molecular biology of the parathyroid / [edited by] Tally Naveh-Many. p. ; cm. -- (Molecular biology intelligence unit) Includes bibliographical references and index. ISBN 0-306-47847-1 1. Parathyroid glands--Molecular aspects. 2. Parathyroid hormone. I. Naveh-Many, Tally. II. Series: Molecular biology intelligence unit (Unnumbered) [DNLM: 1. Parathyroid Glands--physiology. 2. Molecular Biology. 3. Parathyroid Glands--physiopathology. 4. Parathyroid