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PHAGOCYTOSIS" THE HOST Volume 5 9 1999 ADVANCES IN CELL AND MOLECULAR BIOLOGY OF MEMBRANESAND ORGANELLES DEDICATION This volume is dedicated to the memory of Zanvil A. Cohn, mentor and friend. PHAGOCYTOSIS: THE HOST Volume 5 91999 ADVANCES IN CELL AND MOLECULAR BIOLOGY OF MEMBRANES AND ORGANELLES Series Editor: ALAN M. TARTAKOFF Institute of Pathology Case Western Reserve University Volume Editor: SIAMON GORDON Sir William Dunn School of Pathology University of Oxford JAI PRESS INC. Stamford, Connecticut Copyright 91999 JAI PRESSINC. 1(30 Prospect Street Stamford, Connecticut 06901 All rights reserved. No part of this publication may be reproduced, stored on a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, filming, recording, or otherwise, without prior permission in writing from the publisher. ISBN: 1-55938-999-0 Transferred to digital printing 2006 CONTENTS LIST OF CONTRIBUTORS ix INTRODUCTION TO THE SERIES XV PREFACE Siamon Gordon ~176 XVII SECTION I. CONTEXT THE EARLY HISTORY OF PHAGOCYTOSIS Thomas P. Stossel DROSOPHILA HEMOCYTES, PHAGOCYTOSIS, AND CROQUEMORT, A MACROPHAGE RECEPTOR Nathalie C. Franc 19 PHAGOCYTOSIS BY NONPROFESSIONAL PHAGOCYTES Debora Williams-Herman and Zena Werb SECTION II. 47 RECEPTORS SCAVENGER RECEPTORSAND PHAGOCYTOSIS OF BACTERIA AND APOPTOTIC CELLS Nick Platt, Richard Haworth, Rosangela P. da Silva, and Siamon Gordon 71 MANNOSE RECEPTORAND PHAGOCYTOSIS lain P. Fraser and R. Alan B. Ezekowitz 87 INTEGRIN RECEPTORSOF PHAGOCYTES Scott D. Blystone and Eric J. Brown 103 FC RECEPTOR-MEDIATED PHAGOCYTOSIS Steven Greenberg 149 vi CONTENTS SECTION i11. SIGNALING HETEROGENEITY IN MACROPHAGE PHAGOCYTOSIS Alan Aderem and David M. Underhill SIGNALING THROUGH RHO GTPASESIN PHAGOCYTES Arie E. Abo 195 215 REGULATORY ROLESOF PHOSPHATIDYLINOSITOL (4,5) BISPHOSPHATE IN CELLSIGNALING, MEMBRANE TRAFFIC, AND THE CYTOSKELETON Shamshad Cockcroft 233 SECTION IV. THE PATHWAY PATHWAYS THROUGH THE MACROPHAGE VACUOLAR COMPARTMENT Joel A. Swanson 267 SEQUENTIAL MATURATION OF PHAGOSOMES PROVIDES UNIQUE TARGETS FOR PATHOGENS Carmen Alvarez-Dominguez, Luis Mayorga, and Philip D. Stahl PHAGOSOMAL ACIDIFICATION: MECHANISMS AND FUNCTIONAL SIGNIFICANCE David J. Hackam, Off D. Rotstein, and Sergio Grinstein 285 299 THE PHAGOCYTEACTIN CYTOSKELETON Hui-Qiao Sun, Keng-Mean Lin, Masaya Yamamoto, and Helen L. Yin 321 SECTION V. RESPONSES NRAMPI: A NOVEL MACROPHAGE PROTEIN WITH A KEY FUNCTION IN RESISTANCETO INTRACELLULAR PATHOGENS Samantha Gruenheid, Emil Skamene, and Philippe Gros 345 UPTAKE AND PRESENTATION OF PHAGOCYTOSED ANTIGENS BY DENDRITIC CELLS Matthew L. Albert, Shannon Turley, Wendy Garrett, Ira Mellman, Kayo Inaba, Nina Bhardwaj, and Ralph M. Steinman 363 Contents vii PROCESSING AND PRESENTATION OF PHAGOCY'IOSED ANTIGENS TO THE IMMUNE SYSTEM Jean Pieters ANTIMICROBIAL MECHANISMS OF MACROPHAGES Michael U. Shiloh and Carl F. Nathan COMPONENTS AND ORGANIZATION OF THE NADPH OXIDASE OF PHAGOCYTIC CELLS: ITS ROLE IN MICROBIAL KILLING AND IN THE MOLECULAR PATHOLOGY OF CHRONIC GRANULOMATOUS DISEASE Anthony W. Segal, Frans Wientjes, R.W. Stockley, and Lodewijk V. Dekker 379 407 441 OXYGEN-INDEPENDENT ANTIMICR