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<STRONG>Post Genomic Perspectives in Modeling and Control of Breathing is comprised of the proceedings of the IXth Oxford Conference on Modeling and Control of Breathing, held September 13-16, 2003 in Paris, France. This publication is placed within the general framework of post-genomic neurobiology, pathology, and the precise example of the rhythmic respiratory neural assembly being used to understand how genetic networks have been selected and conserved in the vertebrate brain. Specific topics include: ion channels and synapses responsible for respiratory rhythmogenesis and plasticity; pre- and post-natal development of the respiratory rhythm; chemosensory transduction and chemo-afferent signalling. These valuable insights open new avenues as to why the genetic codes underlying a vital function such as breathing have been selected, conserved, or optimized during evolution – a major issue of post-genomic biology. This critical issue will be considered from both top-down and bottom-up integrative modeling standpoints, with a view to elucidating the functional genomics linking discrete molecules to the integrated system that regulates breathing.
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Post-Genomic Perspectives in Modeling and Control of Breathing ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann institute of Science DAV/D KR/TCI-IEVSKY, Wistar institute ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 539 BLADDER DISEASE, Part A and Part B: Research Concepts and Clinical Applications Edited by Anthony Atala and Debra Slade Volume 540 OXYGEN TRANSPORT TO TISSUE, VOLUME XXV Edited by Maureen Thorniley, David K. Harrison, and Philip E. James Volume 541 FRONTIERS IN CLINICAL NEUROSCIENCE: Neurodegeneration and Neuropromction Edited by L~iszl6 Vdcsei Volume 542 QUALITY OF FRESH AND PROCESSED FOODS Edited by Fereidoon Shahidi, Arthur M. Spanier, Chi-Tang Ho, and Terry Braggins Volume 543 HYPOXIA: Through the Lifecycle Edited by Robert C. Roach, Peter D. Wagner, and Peter H. Hackett Volume 544 PEROXISOMAL DISORDERS AND REGULATION OF GENES Edited by Frank Roels, Myriam Baes, and Sylvia De Bie Volume 545 HYPOSPADIAS AND GENITAL DEVELOPMENT Edited by Laurence S. Baskin Volume 546 COMPLEMENTARY AND ALTERNATIVE APPROACHES TO BIOMEDICINE Edited by Edwin L. Cooper and Nobuo Yamaguchi Volume 547 ADVANCES IN SYSTEMS BIOLOGY Edited by Lee K. Opresko, Julie M. Gephart, and Michaela B. Mann Volume 548 RECENT ADVANCES IN EPILEPSY RESEARCH Edited by Devin K. Binder and Helen E. Scharfman Volume 549 HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN Edited by Andrew J. Pollard, George H. McCracken, Jr., and Adam Finn Volume 550 BRAIN DEATH AND DISORDERS OF CONSCIOUSNESS Edited by Calixto Machado and D. Alan Shewmon Volume 551 POST-GENOMIC PERSPECTIVES IN MODELING AND CONTROL OF BREATHING Edited by Jean Champagnat, Monique Denavit-Saubi6, Gilles Fortin, Arthur S. Foutz, Muriel Thoby-Brisson A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumesare billed only upon actual shipment. For further information please contact the publisher. POST-GENOMIC PERSPECTIVES IN MODELING AND CONTROL OF BREATHING Edited by Jean Champagnat Monique Denavit-Saubi6 Gilles Fortin Arthur S. Foutz Muriel Thoby-Brisson CNRS, UPR2216, Genetic & Integrative Neurobiology, Gif sur Yvette, France Kluwer Academic/Plenum Publishers New York, Boston, Dordrecht, London, Moscow Proceedings of the IXth Oxford Conference on Modeling and Control of Breathing, held September 13-16 in Paris, France ISSN 0065-2598 ISBN 0-306-48507-9 © 2004 by Kluwer Academic/Plenum Publ