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This book brings together biochemical, genetic, molecular biology, and clinical approaches to the study of fatty acid oxidation. Including current research from most of the major groups working in this field, it provides a multi-disciplinary approach to the subject and an up-to-date overview of the most recent developments and debates.
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CURRENT VIEWS OF FATTY ACID OXIDATION AND KETOGENESIS From Organelles to Point Mutations ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 462 ADVANCES IN BLADDER RESEARCH Edited by Laurence S. Baskin and Simon W. Hayward Volume 463 ENZYMOLOGY AND MOLECULAR BIOLOGY OF CARBONYL METABOLISM 7 Edited by Henry Weiner, Edmund Maser, David W. Crabb, and Ronald Lindahl Volume 464 CHEMICALS VIA HIGHER PLANT BIOENGINEERING Edited by Fereidoon Shahidi, Paul Kolodziejczyk, John R. Whitaker, Agustin Lopez Munguia, and Glenn Fuller Volume 465 CANCER GENE THERAPY: Past Achievements and Future Challenges Edited by Nagy A. Habib Volume 466 CURRENT VIEWS OF FATTY ACID OXIDATION AND KETOGENESIS: From Organelles to Point Mutations Edited by P. A. Quant and S. Eaton Volume 467 TRYPTOPHAN, SEROTONIN, AND MELATONIN: Basic Aspects and Applications Edited by Gerald Heuther, Walter Kochen, Thomas J. Simat, and Hans Steinhart Volume 468 THE FUNCTIONAL ROLES OF GLIAL CELLS IN HEALTH AND DISEASE: Dialogue between Glia and Neurons Edited by Rebecca Matsas and M. Tsacopoulos Volume 469 EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION, AND RADIATION INJURY, 4 Edited by Kenneth V. Honn, Lawrence J. Marnett, and Santosh Nigam Volume 470 COLON CANCER PREVENTION: Dietary Modulation of Cellular and Molecular Mechanisms Edited by AICR Volume 471 OXYGEN TRANSPORT TO TISSUE XXI Edited by Andras Eke and David T. Delpy A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. CURRENT VIEWS OF FATTY ACID OXIDATION AND KETOGENESIS From Organelles to Point Mutations Edited by Patti A. Quant and Simon Eaton Unit of Paediatric Surgery Institute of Child Health & Great Ormond Street Hospital for Children NHS Trust University College London Medical School London, United Kingdom KLUWER ACADEMIC PUBLISHERS NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW eBook ISBN: Print ISBN: 0-306-46818-2 0-306-46200-1 ©2002 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow All rights reserved No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at: and Kluwer's eBookstore at: http://www.kluweronline.com http://www.ebooks.kluweronline.com Dedication Patti Quant would like to dedicate this book to her mother, Kathleen Isobel Roe and to the memory of her father, Walter George Roe. Simon Eaton would like it to be dedicated to his grandfather, Clement Eaton. This Page Intentionally Left Blank PREFACE In September 1991, Victor Zammit and I were in the Department of Biochemistry, the University of Cambridge, discussing our collaborative research project when we realized the potential value and need for a conference specifically concerned with fatty acid oxidation and ketogenesis. The idea, once seeded, was indulged and fl