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Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications critically evaluates the basic concepts and methodologies of conventional biomarkers as well as current state-of-the-art assays for measuring antioxidant activity/oxidative stress and their practical applications. . Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications will be of a great interest to scientists who are involved in basic research on oxidation, applied scientists evaluating the effects of nutraceuticals or pharmaceutical compounds on antioxidant activity/oxidative stress, and physicians who want to understand the degree of oxidative damage in patients with certain chronic diseases.Discovering sensitive and specific biomarkers for systemic oxidative damage is essential to understand the role of oxidative stress in human disease. Once these roles are clearly understood, we are able to identify novel drug and nutraceutical targets. This volume goes beyond conventional analytical methods of measuring overall antioxidant activity and provides insight to the discovery of biomarkers that reveal information on specific areas of oxidative stress. Contributed by an international list of experts, Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications describes both conventional biomarkers and recent developments in this area.Special Features:Discusses conventional biomarkers as well as recent advances for measuring antioxidants and oxidative stressBiomarkers for lipid peroxidation: isoprostane, hydroxyloctadecaenoic acid, oxysterols, and reactive carbonyl species from lipid peroxidationBiomarkers for protein oxidation: carbonylation, tyrosine oxidation, ubiquitin-conjugationBiomarkers for DNA oxidative damage: comet assay, hydroxylated nucleotides, and exocylcic DNA adductsRecently developed biomarkers from cutting-edge technology
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Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications Edited By Giancarlo Aldini Kyung-Jin Yeum Etsuo Niki Robert M. Russell A John Wiley & Sons, Inc., Publication Edition f rst published 2010 © 2010 Blackwell Publishing Blackwell Publishing was acquired by John Wiley & Sons in F ebruary 2007. Blackwell’s publishing program has been mer ged with Wiley’s global Scientif c, Technical, and Medical business to for m Wiley-Blackwell. Editorial Off ce 2121 State Avenue, Ames, Iowa 50014-8300, USA For details of our global editorial off ces, for customer ser vices, and for infor mation about how to apply for per mission to reuse the cop yright material in this book, please see our Website at www.wiley.com/wiley-blackwell. Authorization to photocopy items for inter nal or personal use, or the inter nal or personal use of specif c clients, is g ranted by Blackwell Publishing, provided that the base fee is paid directl y to the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been g ranted a photocopy license by CCC, a separate system of pa yments has been ar ranged. The fee code for users of the Transactional Reporting Service is ISBN-13: 978-0-8138-1535-0/2010. Designations used by companies to distinguish their products are often claimed as trademarks. All brand names and product names used in this book are trade names, ser vice marks, trademarks, or registered trademarks of their respecti ve owners. The publisher is not associated with an y product or vendor mentioned in this book. This publication is designed to pro vide accurate and authoritative information in regard to the subject matter co vered. It is sold on the understanding that the publisher is not eng aged in rendering professional ser vic