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MHJ161_2_toc 2/2/11 2:24 PM Page 1 American Heart Journal www.ahjonline.com Table of Contents February 2011, Volume 161, Number 2 Editorial Curriculum in Cardiology 221 Challenge of rehospitalizations for heart failure: 241 Atrial fibrillation, anticoagulation, fall risk, and outcomes in elderly patients Potential of natriuretic doses of mineralocorticoid receptor antagonists Robert W. Schrier, MD and Mihai Gheorghiade, MD, Denver, CO; and Chicago, IL Matthew B. Sellers, MD and L. Kristin Newby, MD, MHS, Durham, NC 247 Primary percutaneous coronary intervention for acute myocardial infarction: Is it worth the wait?: The risktime relationship and the need to quantify the impact of delay Special Articles 224 Clinical development of pharmacologic agents for acute Giuseppe Tarantini, MD, PhD, Frans Van de Werf, MD, PhD, Claudio Bilato, MD, PhD, and Bernard Gersh, MB, ChB, DPhil, FRCP, Padua, Italy; Leuven, Belgium; and Rochester, NY heart failure syndromes: A proposal for a mechanistic translational phase Mihai Gheorghiade, MD, Peter S. Pang, MD, Christopher M. O’Connor, MD, Krishna Prasad, MD, John McMurray, MD, John R. Teerlink, MD, Mona Fiuzat, PharmD, Hani Sabbah, PhD, and Michel Komajda, MD, Chicago, IL; Durham, NC; London, England; Glasgow, United Kingdom; San Francisco, CA; Detroit, MI; and Paris, France 233 Lessons learned from a pediatric clinical trial: The Pediatric Heart Network Angiotensin-Converting Enzyme Inhibition in Mitral Regurgitation Study Jennifer S. Li, MD, MHS, Steven D. Colan, MD, Lynn A. Sleeper, ScD, Jane W. Newburger, MD, MPH, Victoria L. Pemberton, RNC, MS, Andrew M. Atz, MD, Meryl S. Cohen, MD, Fraser Golding, MD, Gloria L. Klein, Ronald V. Lacro, MD, Elizabeth Radojewski, RN, Marc E. Richmond, MD, and L. LuAnn Minich, MD, Durham, NC; Watertown and Boston, MA; Bethesda, MD; Charleston, SC; Philadelphia, PA; Ontario, Canada; New York, NY; and Salt Lake City, UT Trial Design 254 Design and rationale of the RadIal Vs. femorAL access for coronary intervention (RIVAL) trial: A randomized comparison of radial versus femoral access for coronary angiography or intervention in patients with acute coronary syndromes Sanjit S. Jolly, MD, MSc, Kari Niemelä, MD, PhD, Denis Xavier, MD, Petr Widimsky, MD, Andrzej Budaj, MD, PhD, Vicent Valentin, MD, Basil S. Lewis, MD, Alvaro Avezum, MD, PhD, Philippe Gabriel Steg, MD, Sunil V. Rao, MD, John Cairns, MD, Susan Chrolavicius, BScN, Salim Yusuf, MBBS, D.Phil, and Shamir R. Mehta, MD, MSc, Ontario and Vancouver, Canada; Tampere, Finland; Bangalore, India; Prague, Czech Republic; Warsaw, Poland; Valencia, Spain; Haifa, Israel; Sao Paulo, Brazil; Paris, France; and Durham, NC American Heart Journal (ISSN 0002-8703) is published monthly by Mosby, 360 Park Avenue South, New York, NY 10010-1710. Periodicals postage paid at New York, NY and additional mailing offices. POSTMASTER: Send address changes to American Heart Journal, Elsevier Customer Service Department, 3251 Riverport Lane, Maryland Heights, MO 63043, USA. American Heart Journal 1A Contents 261 continued A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: Design and rationale of the RADAR Phase IIb trial Thomas J. Povsic, MD, PhD, Mauricio G. Cohen, MD, Roxana Mehran, MD, Christopher E. Buller, MD, Christoph Bode, MD, Jan H. Cornel, MD, Jaroslaw D. Kasprzak, MD, Gilles Montalescot, MD, Diane Joseph, William A. Wargin, PhD, Christopher P. Rusconi, PhD, Steven L. Zelenkofske, DO, Richard C. Becker, MD, and John H. Alexander, MD, MHS, Durham, and Chapel Hill, NC; Miami, FL; New York,