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<STRONG>Inke Näthke is the professor of Epithelial Biology at the University of Dundee. Her research interest is to determine how specific molecular changes produce changes in cells and ultimately in whole tissues during early stages of tumourigenesis. Her focus is on colorectal cancers but the common epithelial origin of most tumours makes this work relevant to many other organs. Her work has led her to examine not only how cells move and divide but also how they know where they are, and how they work together to build a functional tissue. Professor Näthke received her training at San Jose State University, the University of California San Francisco, Stanford and Harvard Medical Schools.
<STRONG>Brooke McCartney is an Assistant Professor of Biological Sciences at Carnegie Mellon University. She is interested in how signaling pathways regulate the cytoskeleton and how this leads to changes in cytoskeletal and tissue architecture. The focus of her lab is the role of APC proteins and Wnt signaling in morphogenesis, both at the level of the cytoskeleton and at the level of tissues, using Drosophila melanogaster as a model system. Dr. McCartney received her training at Mount Holyoke College, Duke University, and the University of North Carolina at Chapel Hill.
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APe Proteins ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY EditorialBoard: NATHAN BACK, State University ofNew York at Buffalo IRUN R. COHEN, The Weizmann Institute ofScience ABEL LAJTHA, N.S. KlineInstitutefor Psychiatric Research JOHN D. LAMBRIS, University ofPennsylvania RODOLFOPAOLETII, University ofMilan Recent Volumes in this Series Volume 649 MOLECULAR MECHANISMS OF SPONDYLOARATHROPATHIES Edited by CarlosLopez-Larrea, and RobertoDiaz-Pefia Volume 650 V(D)J RECOMBINATION Edited by PierreFerrier Volume 651 DEVEOPLMENT AND ENGINEERING OF DOPAMINE NEURONS Edited by R. Jeroen Pasterkamp, Marten P. Smidt, and J. Peter H. Burbach Volume 652 INHERITED NEUROMUSCULAR DISEASES: TRANSLATION FROM PATHOMECHANISMS TO THERAPIES Edited by CarmenEspinos,Vicente Felipo, and FrancesePalau Volume 653 TARGETPATTERN RECOGNITION IN INNATE IMMUNITY Edited by Uday Kishore Volume 654 THE ISLETSOF LANGERHANS Edited by Md. ShahidulIslam Volume 655 PHARMACEUTICAL BIOTECHNOLOGY Edited by CarlosA. Guzmanand Giora Z. Feuerstein Volume 656 APC PROTEINS Edited by Inke S. Niithke and Brooke M. McCartney AContinuation Order Plan isavailable forthisseries. Acontinuationorderwillbring delivery of eachnew volume immediately upon publication. Volumes are billedonly uponactual shipment. Forfurther information please contact thepublisher. APe Proteins Edited by Inke S. Niithke Celland Developmental Biology, College ofLife Sciences, University ofDundee, Dundee, Scotland, UK Brooke M. McCartney Department ofBiological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA Springer Science+Business Media, LLC Landes Bioscience Springer Science+Business Media, LLC Landes Bioscience Copyright ©2009 Landes Bioscience and Springer Science+Business Media, LLC All rights reserved. No part ofthis book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher, with the exception ofany material supplied specifically for the purpose of being entered and executed on a computer system ; for exclus ive use by the Purchas er of the work . Printed in the USA . Springer Science+Business Media, LLC, 233 Spring Street, New York, New York 10013, USA http ://www.springer.com Please address all inquiries to the publishers: Landes Bioscience, 1002 West Avenue, Austin, Texas 7870 I, USA Phone : 512/6376050; FAX: 512/6376079 http ://www.landesbioscie