E-Book Overview
ADVANCES IN CANCER RESEARCH is a biannual publication that includes timely reviews on the most cutting-edge issues in cancer research. Volume 66 contains encompassing overviews of p53 and its role in both breast cancer and in the cell cycle. Approximately 50% of all human tumors involve mutations of the p53 gene, suggesting that proper understanding of its properties and mechanisms could offer real hope for finding successful clinical therapy. Other themes presented in Volume 66 include cyclins and cyclin-dependent kinases in the cell cycle. Approximately 50% of all human tumors involve mutations of the p53 gene, suggesting that proper understanding of its properties and mechanisms could offer real hope for finding sucessful clinical therapy. Other themes presented in Volume 66 include cyclins and cyclin-dependant kinases in the cell cycle: the molecular genetics of 11q23 chromosome translocations: the possible link between the aberrant expression of Scatter Factor and c-Met with AIDS Associated kaposi's Sarcoma, the use of Radiation Leukemia Virus to induce leukemogenesis, and the Adenovirus system as a model for the insertion of foreign DNA into mammalian genomes. Also of note in the ''Foundations of cancer Research'' section are articles by two prominent cancer researchers recollecting the ideas and paths taken in their lifelong work. Paradigms proposed in these reviews mark thoughtful progress toward preventative therapy in oncogenesis and gene therapy of cancer. They also cast light on the fact that the ideas presented in these chapters are only the tip of the iceburg in this complex and ever evolving field, and suggest many more to come in future volumes. Key Features * Contains two Foundations in Cancer Research articles with personal accounts by prominent biologists on their careers in cancer research * Presents overviews of the role of p53 in breast cancer and cell cycle regulation * Describes the regulatory role of cyclins and cyclin dependent kinases in DNA replication and cell division * Explains the puzzling link between HIV infection and Kaposis Sarcoma * Includes models for retrovirus-induced tumorigenesis and foreign DNA insertion into mammalian genomes
E-Book Content
ADVANCES IN CANCER RESEARCH VOLUME 66 This Page Intentionally Left Blank ADVANCES IN CANCERRESEARCH Edited by GEORGE F. VANDE WOUDE ABL-Basic Research Program NCI-Frederick Cancer Research and Development Center Frederick, Maryland GEORGE KLEIN Department of Tumor Biology Karolinska lnstitutet Stockholm, Sweden Volume 66 ACADEMIC PRESS San Diego New York Boston London Sydney Tokyo Toronto This book is printed on acid-free paper. @ 0 1995 by ACADEMIC PRESS, INC. All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Academic Press, Inc. A Division of Harcourt Brace & Company 525 B Street, Suite 1900, San Diego, California 92101-4495 United Kingdom Edition published by Academic Press Limited 24-28 Oval Road. London NWl 7DX International Standard Serial Number: 0065-230X International Standard Book Number: 0- 12-006666-1 PRINTED IN THE UNlTED STATES OF AMERICA 95 96 9 7 9 8 99 0 0 B B 9 8 7 6 5 4 3 2 1 CONTENTS CONTRIBUTORS TO VOLUME66 . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . X FOUNDATIONS IN CANCER RESEARCH The Adventures of a Biologist: Prenatal Diagnosis, Hematopoiesis, Leukemia, Carcinogenesis, and Tumor Suppression LEO SACHS I. IV. V. Studies in England and Move to Israel: Amniocentesis and Prenatal and Irradiation