16 December 2005 Vol. 310 No. 5755 Pages 1725–1852 $10 A M P L I F I C AT I O N CELL BIOLOGY CLONING MICROARRAYS NUCLEIC ACID ANALYSIS PROTEIN FUNCTION & A NALYS I S QUANTITATIVE PCR SOFTWARE SOLUTIONS Mx3005P™ System Mx3000P System Most Flexible Most Affordable ® Performance runs in the family. Choose the personal QPCR system that’s right for you. Stratagene now offers two affordable, fully-featured quantitative PCR (QPCR) systems. The new five-color Mx3005P ™ QPCR System includes expanded features to support a wider range of real-time QPCR applications, such as simultaneous five-target detection and alternative QPCR probe chemistries. • A four- or five-color instrument, with user-selected filters • Advanced optical system design for true multiplexing capability, and wider application support The Mx3000P ® QPCR System is still the most affordably priced four-color • QPCR Software with enhanced data analysis and export functionality 96-well system available. Need More Information? Give Us A Call: Stratagene USA and Canada Order: (800) 424-5444 x3 Technical Services: (800) 894-1304 x2 Stratagene Europe Order: 00800-7000-7000 Technical Services: 00800-7400-7400 Stratagene Japan K.K. Order: 03-5159-2060 Technical Services: 03-5159-2070 www.stratagene.com Mx3000P ® is a registered trademark of Stratagene in the United States. Mx3005P ™ is a trademark of Stratagene in the United States. Purchase of this product is accompanied by a license under the foreign counterparts of U.S. Patent Nos. 4,683,195, 4,683,202 and 4,965,188 covering the Polymerase Chain Reaction (“PCR”) process, where such process is covered by patents. This instrument is an Authorized ThermalCycler for use with applications licenses available from Applied Biosystems. Its use with Authorized Reagents also provides a limited PCR license in accordance with the label rights accompanying such reagents. GE Healthcare Why do 100,000 scientists trust GE Healthcare for all their protein purification needs? Here’s Ä clue. To 100,000 scientists worldwide, the name ÄKTA™ has always meant outstanding protein purification, and now it’s brought to you by GE Healthcare. With the ability to purify virtually 100% of all biomolecules, the ÄKTAdesign™ platform can handle the toughest of challenges. Whatever the scale, from laboratory, to process development and manufacturing, there’s an ÄKTAdesign system to meet every need. All systems in the ÄKTAdesign family work with the intelligent UNICORN™ software, which makes it easy to control every stage of your purification processes. Accurate, reproducible results just take a little pure imagination. Visit www.amershambiosciences.com/aktadesign © 2005 General Electric Company - All rights reserved. Amersham Biosciences AB, a General Electric company going to market as GE Healthcare. GE15-05 COVER The cellular changes of lightly pigmented golden zebrafish show a striking resemblance to those of lighter skinned humans. The zebrafish pigment gene slc24a5 is functionally conserved across evolution; a single base change in its human ortholog may play a role in pigment variation in human populations. See page 1782. [Image: J. Mest and J. Cheng] DEPARTMENTS 1735 1737 1741 1743 1746 1747 1828 1829 1760 1762 ELECTRONICS Organic LEDs Look Forward to a Bright, White Future 1764 RANDOM SAMPLES NEWS OF THE WEEK 1767 Asian Scientists and the “Glass Ceiling” M.-C. Hung et al.; R. Mejia et al.; D. Jiang; J. B. Stewart; L. J. Pike. How to Cut World Hunger in Half P. Lindskog. Cognitive Unbinding in Sleep and Anesthesia G.