Mechanisms Of Vascular Disease: A Textbook For Vascular Surgeons

This page intentionally left blank Mechanisms of Vascular Disease A Textbook for Vascular Surgeons This textbook provides an up-to-date account of the mechanisms and pathophysiology of vascular disease, and the current treatment options open to vascular surgeons. As the scientific basis of vascular disease advances rapidly, it is critical that clinicians have access to relevant information written specifically for vascular surgeons. This account reviews the impact of these scientific advances on established and emerging treatment options. Experts from Australia, North America and Europe have contributed to basic topics such as atherosclerosis, restenosis, thrombosis and haemostasis, ischaemia-reperfusion injury, sepsis, vascular haemodynamics and wound healing. More applied topics such as pain syndromes in vascular surgery and the diabetic foot are also covered in this textbook. This will be a core text for all vascular surgical trainees and vascular surgeons, and specially appropriate for advanced trainees and consultants wishing to refresh their knowledge base. R F is Associate Professor of Surgery at the University of Adelaide and Head of Vascular Surgery at the Queen Elizabeth Hospital, Woodville, Australia. M T is Professor of Vascular Surgery at St George’s Hospital Medical School, London, UK. Mechanisms of Vascular Disease A Textbook for Vascular Surgeons Robert Fitridge The Queen Elizabeth Hospital, Woodville, Australia Matthew Thompson St George’s Hospital Medical School, London, UK cambridge university press Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, São Paulo Cambridge University Press The Edinburgh Building, Cambridge cb2 2ru, UK Published in the United States of America by Cambridge University Press, New York www.cambridge.org Information on this title: www.cambridge.org/9780521860635 © Cambridge University Press 2006 This publication is in copyright. Subject to statutory exception and to the provision of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published in print format 2006 isbn-13 isbn-10 978-0-511-26010-0 eBook (EBL) 0-511-26010-5 eBook (EBL) isbn-13 isbn-10 978-0-521-86063-5 hardback 0-521-86063-6 hardback Cambridge University Press has no responsibility for the persistence or accuracy of urls for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. Contents List of contributors vii 1 The vascular endothelium: structure and function 1 , 13 Restenosis: treatment options – current and future 191 , , ,