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Intended for researchers in immunology, cell biology, virology and medicine, this book provides information on such topics as cytokine gene regulation, and animal models for acquired immunodeficiency syndrome.
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ADVANCES IN Immunology EDITED BY FRANK J. DIXON Scripps Clinic and Research Foundation La Jolla, California ASSOCIATE EDITORS K. FRANK AUSTEN LEROYE. HOOD JONATHAN W. UHR TADAMITSU KISHIMOTO FRITZMELCHERS VOLUME 52 ACADEMIC PRESS, INC. Harcourt Brace Jovanovich, Publishers San Diego New York Boston London Sydney Tokyo Toronto This book is printed on acid-free paper. @ Copyright 0 1992 by ACADEMIC PRESS, INC. All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Academic Press, Inc. 1250 Sixth Avenue, San Diego, California 92101-4311 United Kingdom Edition published by Academic Press Limited 24-28 Oval Road, London NW I 7DX Library of Congress Catalog Number: 61-17057 International Standard Book Number: 0-12-022452-6 PRINTED IN THE UNITED STATES OF AMERICA 9 2 9 3 9 4 9 5 9 6 9 1 BB 9 8 1 6 5 4 3 2 1 ADVANCES IN IMMUNOLOGY,VOL. 52 Cytokine Gene Regulation: Regulatory &-Elements and DNA Binding Factors Involved in the Interferon System NOBUYUKI TANAKA AND TADATSUGU TANlGUCHl Institute for Molecular ond Cellulor Biology, Osaka University, Yamadaoka 1-3, Suita-shi, Osaka 565, Japan 1. Introduction Cytokines constitute a class of soluble mediators involved in cell-tocell communication and pla