PRINCIPLES OF MOLECULAR ONCOLOGY EDITED BY MIGUEL H. BRONCHUD, MD, PhD M ARYANN FOOTE, PhD WILLIAM P. PETERS, MD, PhD MURRAY O. ROBINSON, PhD HUMANA PRESS Principles of Molecular Oncology Principles of Molecular Oncology Edited by Miguel H. Bronchud, MD, PhD Hospital General of Granollers, Barcelona, Spain MaryAnn Foote, PhD Amgen Inc., Thousand Oaks, CA William P. Peters, PhD Barbara Ann Karmonos Cancer Institute, The Detroit Medical Center Wayne State University, Detroit, MI Murray O. Robinson, MD, PhD Amgen Inc., Thousand Oaks, CA Forewords by E. Donnall Thomas and David J. Weatherall Humana Press Totowa, New Jersey © 2000 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. All authored papers, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily reflect the views of the publisher. For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at the above address or at any of the following numbers: Tel.: 973-256-1699; Fax: 973-256-8341; E-mail: