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256 pages, 67 figures, 6 tables, hardcover This monograph is the first of its kind to focus specifically on the role of astroglia in aging-related human neurodegenerative disorders and experimental models of CNS senescence and degeneration. As such, this volume in the Neuroscience Intelligence Unit Series represents a novel and important contribution to the basic and clinical neuroscience literature. The chapters are grouped into three sections: I. Biology of Astrocytes. The chapters in this section will constitute a comprehensive discussion of the known functions of astroglia in the mammalian CNS and the roles these cells may play in the pathophysiology of neurological disorders. II. Astrocytes in Human Brain Senescence and Neurodegenerative Disorders. In this section, the pathology of astrocytes and their putative roles in human CNS senescence and various neurodegenerative conditions are covered in considerable detail. III. Experimental Models of Astrocyte Senescence: Implications for Neurodegenerative ! Disease. In this final section, experimental approaches to the delineation of the role of astroglia in brain aging and degeneration are described. This book should appeal widely to basic neuroscientists interested in various aspects of the biology of these cells as well as to clinically-oriented investigators concerned with the pathogenesis of the major human neurodegenerative disorders.
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NEUROSCIENCE I N T E L L I G E N C E U N I T
3
Hyman M. Schipper
Astrocytes in Brain Aging and Neurodegeneration
R.G. LANDES C OM PA N Y
NEUROSCIENCE INTELLIGENCE UNIT
Astrocytes in Brain Aging and Neurodegeneration Hyman M. Schipper Department of Neurology and Neurosurgery Department of Medicine (Geriatrics) and Centre for Studies in Aging McGill University and Bloomfield Centre for Research in Aging Lady Davis Institute for Medical Research Sir Mortimer B. Davis-Jewish General Hospital Montreal, Quebec, Canada
R.G. LANDES COMPANY AUSTIN, TEXAS U.S.A.
NEUROSCIENCE INTELLIGENCE UNIT Astrocytes in Brain Aging and Neurodegeneration R.G. LANDES COMPANY Austin, Texas, U.S.A. Copyright © 1998 R.G. Landes Company All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Printed in the U.S.A. Please address all inquiries to the Publishers: R.G. Landes Company, 810 South Church Street, Georgetown, Texas, U.S.A. 78626 Phone: 512/ 863 7762; FAX: 512/ 863 0081
ISBN: 1-57059-489-9
While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein.
Library of Congress Cataloging-in-Publication Data
Astrocytes in brain aging and neurodegeneration / [edited by] Hyman M. Schipper. p. cm. -- (Neuroscience intelligence unit) ISBN 1-57059-489-9 (alk. paper) 1. Nervous system--Degeneration. 2. Nervous system--Aging. 3. Astrocytes. I. Schipper, Hyman M., 1954- . II. Series. [DNLM: 1. Neurodegenerative Diseases--physiopathology. 2. Astrocytes-physiology. 3. Brain Diseases--physiopathology. 4. Brain--physiology. 5. Aging-physiology. WL 300A859 1998] RC365.A88 1998 616.8'047--dc21 DNLM/DLC 98-26335 for Library of Congress CIP<