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CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY VOLUME 6 ADVISORY BOARD JEAN BRACHET ERASMO M A R R ~ JAMES D. EBERT JOHN PAUL E. PETER GEIDUSCHEK HOWARD A. SCHNEIDERMAN EUGENE GOLDWASSER RICHARD L. SIDMAN PAUL R. GROSS HERBERT STERN CONTRIBUTORS JOHN TYLER BONNER J. R. TATA EDWARD C. CANTINO LOUIS C. TRUESDELL STUART KAUFFMAN J. E. VARNER A. A. NEYFAKH LEWIS WOLPERT H. YOMO CURRENT TOPICS IN DEVELOPMENTAL B I O L O G Y EDITED BY A. A. MOSCONA DEPARTMENT OF BIOLOGY T H E UNIVERSITY OF CHICAGO CHICAGO, ILLINOIS ALBERT0 MONROY C.N.R. LABORATORY OF MOLECULAR EMBRYOLOGY ARCO FELICE (NAPLES), ITALY VOLUME 6 1971 @ ACADEMIC PRESS New York London COPYRIGHT 0 1971, BY ACADEMIC PRESS,INC, ALL RIGHTS RESERVED NO PART OF THIS BOOK MAY BE REPRODUCED IN ANY FORM, BY PHOTOSTAT, MICROFILM, RETRIEVAL SYSTEM, OR ANY OTHER MEANS, WITHOUT WRIlTEN PERMISSION FROM THE PUBLISHERS. ACADEMIC PRESS, INC. 111 Fifth Avenue, New York, New York 10003 United Kingdom Edition published by ACADEMIC PRESS, INC. (LONDON) LTD. 24/28 Oval Road, London NWl IDD LIBRARY OF CONGRESS CATALOG CARD NUMBER:66-28604 PRINTED IN THE UNITED STATES OF AMERICA List of Contributors ........................................................ ix ............................................. xi Contents of Previous Volumes The Direction of Developmental Biology JOHN TYLER BONNER............................. XV .......................................................... xxi Errata Volume 5 CHAPTER 1 . The Induction and Ear