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Volume 438 Number 7069 pp711-888 In this issue (8 December 2005) • Editorials • Research Highlights • News • News Features • Business • Correspondence • Books and Arts • Essay • News and Views Also this week • Editor's Summary • Authors • Nature Podcast • Brief Communications • Brief Communications Arising (this content only available online) • Huygens News & Views • Huygens Articles • Huygens Letters • Articles • Letters • Naturejobs • Futures Editorials Unapproved tests on a chip p711 Prenatal genetic tests can now check for abnormalities in developing fetuses, but there is still no regulatory framework for them in the United States. Launching a business p711 There's little evidence that commercial approaches can radically reduce the cost of getting into space. Enough, already p712 No convincing case has been made for increasing the amount of plutonium held at a Californian lab. Research Highlights Research highlights p714 News UK animal labs still under siege p716 Activists maintain pressure as building of Oxford lab resumes. Tom Simonite and Jim Giles Animal-rights militancy exported to US and Europe p717 Rise in extremist activity abroad 'aided by British expertise'. Emma Marris and Tom Simonite TV show gives research lobbyist a rat's-eye view of laboratory life p717 Pro-animal researcher runs the gauntlet of tests. Sidelines p718 TV tests call into question cloner's stem-cell success p718 Korean star faces challenges over data. David Cyranoski Avian flu centre put under threat of closure p719 Indonesian authorities halt research at frontline station. Declan Butler Climate talks edge towards twin-track future p721 UN convention could complement Kyoto Protocol. Amanda Haag Prospect of stricter timekeeping alarms US biologists p721 Hackles are raised over revamped guidelines. Emma Marris German hostage was saving Iraq digs p722 Kidnapped archaeologist fought against looting. A