Modern Pharmaceutics Fourth Edition Revised And Expanded

Modern Pharmaceutics Fourth Edition, Revised and Expanded edited by Gilbert S. Banker University of Iowa Iowa City, Iowa Christopher T. Rhodes University of Rhode Island Kingston, Rhode Island Marcel Dekker, Inc. TM Copyright © 2002 by Marcel Dekker, Inc. All Rights Reserved. Copyright © 2002 Marcel Dekker, Inc. New York • Basel # ! "$" $ % &# ! "'( )() ! !" * + , ) - '! .+ ) ! / 0 1 # )! "! "! ')' % &# )! "! "! ''$" ! # 2 3 4 5 2 2 0 0 - , 4 " # $ # # % & ! '' ( &) *!! + $ + , ) 6 2 6 2 6 2 6 6 2 2 , 6 , 2 7 2 , , 6 6 2 , 6 2 2 , 2 . , 8 , 9# ! $ ' " ( ) : ! -+ . . / . .*. 01 *% + "* Copyright © 2002 Marcel Dekker, Inc. DRUGS AND THE PHARMACEUTICAL SCIENCES Executive Editor James Swarbrick PharmaceuTech, Inc. Pinehurst, North Carolina Advisory Board Larry L. Augsburger University of Maryland Baltimore, Maryland Douwe D. Breimer Gorlaeus Laboratories Leiden, The Netherlands David E. Nichols Purdue University West Lafayette, Indiana Stephen G. Schulman University of Florida Gainesville, Florida Trevor M. Jones The Association of the British Pharmaceutical Industry London, United Kingdom Jerome P. Skelly Alexandria, Virginia Hans E. Junginger Leiden/Amsterdam Center for Drug Research Leiden, The Netherlands Felix Theeuwes Alza Corporation Palo Alto, California Vincent H. L. Lee University of Southern California Los Angeles, California Geoffrey T. Tucker University of Sheffield Royal Hallamshire Hospital Sheffield, United Kingdom Peter G. Welling Institut de Recherche Jouveinal Fresnes, France Copyright © 2002 Marcel Dekker, Inc. Preface 7 !$' !$'$ !$$( , 2 6 & , 2 6 2 2 0 2 , 7 2 ; 6 < ="" ="" ="" ,="" ="" ,="" ="" ="" ="" ="" 2="" =""> < ="" ="" ="" ,="" ="" ="" ="" ="" ="" ="" ="" ="" =""> = , , 7 6 6 = , 22 ,, 6 2 , 2 = 2 6 2 , 2 2 2 , 6 2 6 6 2 2 2 , . ! , 6 , , , ,