E-Book Overview
This book introduces students to methods that will help them understand behaviour in terms of cellular components and their interactions in non-intuitive ways, which calls for an interdisciplinary approach combining mathematical, chemical, computational and biological strategies. Tibor Ganti was one of the early pioneers who proposed a theoretical framework to understand living principles in terms of chemical transformation cycles and their coupling. The twenty-first century then brought with it a novel ‘systems’ paradigm, which shone new light on all previous work and was accompanied by numerous implications for the way we conceive of chemical and biological complexity today.
This book seeks to equip students to take advantage of any field that investigates living systems. Based on a conceptualisation of science-oriented branches, engineering-oriented branches and biology as astoundingly complex fields, those structures laden with biochemical detail encompass a deeper theory unifying our knowledge of designed systems.
Readers will be pleasantly surprised at how lucidly the topics are presented. The book offers an indispensable resource for students and professionals working in systems and synthetic biology or any of the various related fields of research.
E-Book Content
Shailza Singh Editor Systems Biology Application in Synthetic Biology Systems Biology Application in Synthetic Biology Shailza Singh Editor Systems Biology Application in Synthetic Biology Editor Shailza Singh Computational and Systems Biology Lab National Centre for Cell Science Pune, India ISBN 978-81-322-2807-3 ISBN 978-81-322-2809-7 DOI 10.1007/978-81-322-2809-7 (eBook) Library of Congress Control Number: 2016952540 © Springer India 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer (India) Pvt. Ltd. Preface Systems and synthetic biology is an investigative and constructive means of understanding the complexities of biology. Discovery of restriction nucleases by Werner Arber, Hamilton Smith, and Daniel Nathans in 1978 revolutionized the way DNA recombinant constructs were made and how individual genes were analyzed for its function and vitality. It also opened the doors to a new era of “synthetic biology” where apart from analysis and description of existing gene, new gene arrangements can be constructed and evaluated. Since then, synthetic biology has emerged from biology as a distinct discipline that quantifies the dynamic physiological processes in the cell in response to a stimulus. Switches, oscillators, digital logic gates, filters, modular – interoperable memory devices, counters,