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Second Edition/Volume II Microbial Technology Fermentation Technology Edited by H. J. PEPPLER Universal Foods Corporation Milwaukee, Wisconsin D. PERLMAN School of Pharmacy University of Wisconsin Madison, Wisconsin ® ACADEMIC PRESS New York San Francisco London 1979 A Subsidiary of Harcourt Brace Jovanovich, Publishers COPYRIGHT © 1979, BY ACADEMIC PRESS, I N C . ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS, INC. Ill Fifth Avenue, New York, New York 10003 United Kingdom Edition published by ACADEMIC PRESS, INC. (LONDON) LTD. 24/28 Oval Road, London NW1 7DX Library of Congress Cataloging in Publication Data Peppier, Henry J Microbial technology. Vol. 2 edited by H. J. Peppier and D. Perlman. Includes bibliographies and index. CONTENTS: v . l . Microbial processes.—v. 2. Fermentation technology. 1. Industrial microbiology. 2. Fermentation. I. Perlman, D. II. Title. [DNLM: 1. Bacteriological technics. 2. Fermentation. QY100 M626] QR53.P45 1979 660'.62 78-67883 ISBN 0 - 1 2 - 5 5 1 5 0 2 - 2 (v. 2) PRINTED IN THE UNITED STATES OF AMERICA 79 80 81 82 9 8 7 6 5 4 3 2 1 List of Contributors Numbers in parentheses indicate the pages on which the authors' contributions begin. Maynard A, Amerlne (131), Department of Viticulture and Enology, University of California, Davis, California 95616 William B. Armiger (375), BioChem Technology, Inc., Great Valley Corporate Center, Malvern, Pennsylvania 19355 William H. Bartholomew (463), Research Department, Stauffer Chemical Company, Westport, Connecticut 06880 Paul A. Belter (403), Fermentation Research & Development, Fine Chemical Division, The Upjohn Company, Kalamazoo, Michigan 49001 W. T. Blevins (303), Auburn University, Botany and Microbiology Department, Auburn, Alabama 36830 L T. Chang (243), Bristol-Myers Company, Industrial Division, Syracuse, New York 13201 Ichiro Chibata (433), Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd., 16-89 Kashima-3-chome, Yodogawa-ku, Osaka, Japan N. D. Davis (303), Auburn University, Botany and Microbiology Department, Auburn, Alabama 36830 Richard P. Elander (243), Bristol-Myers Company, Industrial Division, Syracuse, New York 13201 Stanley M. Finger (179), Department of Chemical Engineering, University of Maryland, College Park, Maryland 20742 Larry L. Gasner (211), Department of Chemical Engineering, University of Maryland, College Park, Maryland 20742 Randolph T. Hatch (179), Department of Chemical Engineering, University of Maryland, College Park, Maryland 20742 XI XII List of Contributors C. W. Hesseltine (95), Northern Regional Research Center, Federal Research, Science and Education Administration, U.S. Department of Agriculture, Peoria, Illinois 61604 N. J. Huige* (1), Jos. Schlitz Brewing Company, Milwaukee, Wisconsin 53212 Arthur E. Humphrey (375), School of Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 W. F. Maisch (79), Research Department, Hiram Walker & Sons, Inc., Peoria, Illinois 61601 Irving Marcus (497), Oblon, Fisher, Spivak, McClelland & Maier, Arlington, Virginia 22202 Gerard J. Moskowitz (201), Dairyland Food Laboratories, Inc., Waukesha, Wisconsin 53187 G. B. Nickol (155), Research Division, U.S. Industrial Chemicals Co., Cincinnati, Ohio 45237 L K. Nyirif (331 ), Department of Chemical Engineering, Lehigh University, Bethlehem, Pennsylvania 18015 Norman F. Olson (39), Department of Food Science, University of Wisconsin, Madison, Wisconsin 53706 D. Perlman (173), School of Pharmacy, University of Wisconsin, Madison, Wisconsin