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Honorary President Lord Todd, PRS Organizing Committee Chairman: J. Michalski Deputy Chairmen: M. Wiewiorowski W. J. Stec Secretary: A. Okruszek Members: K. Golankiewicz P. Mastalerz M. Mikoiajczyk W. Ostrowski D. Shugar A. Skowronska K. L. Wierzchowski J. Wróbel INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY IUPAC Secretariat: Bank Court Chambers, 2-3 Pound Way Cowley Centre, Oxford 0X4 3YF, UK INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY (Organic Chemistry Division) in conjunction with Polish Academy of Sciences (National Committee of Chemistry) (Centre of Molecular and Macromolecular Studies) PHOSPHORUS CHEMISTRY DIRECTED TOWARDS BIOLOGY Lectures Presented at the International Symposium on Phosphorus Chemistry Directed Towards Biology, Burzenin, Poland 25-28 September 1979 Editor W. J. STEC Polish Academy of Sciences Centre of Molecular and MacromoiecuJar Studies Lodz, Poland PERGAMON PRESS OXFORD · NEW YORK · TORONTO · SYDNEY · PARIS · FRANKFURT U.K. U.S.A. CANADA AUSTRALIA FRANCE FEDERAL REPUBLIC OF GERMANY Pergamon Press Ltd., Headington Hill Hall, Oxford 0X3 OBW, England Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, New York 10523, U.S.A. Pergamon of Canada, Suite 104, 150 Consumers Road, Willowdale, Ontario M2J 1P9, Canada Pergamon Press (Aust.) Pty. Ltd., P.O. Box 544, Potts Point, N.S.W. 2011, Australia Pergamon Press SARL, 24 rue des Ecoles, 75240 Paris, Cedex 05, France Pergamon Press GmbH, 6242 Kronberg-Taunus, Hammerweg 6, Federal Republic of Germany Copyright © 1980 International Union of Pure and Applied Chemistry All flights Reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means: electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or otherwise, without permission in writing from the copyright holders. First edition 1980 British Library Cataloguing in Publication Data International Symposium on Phosphorus Chemistry Directed Towards Biology, Burzenin, 1979 Phosphorus chemistry directed towards biology. (International Union of Pure and Applied Chemistry. IUPAC symposium series). 1. Phosphorus in the body - Congresses I. Title II. Stec, W. J. III. International Union of Pure and Applied Chemistry. Organic Chemistry Division IV. Polska Akademie Nauk. National Committee for Chemistry V. Series 574.1'921 QP535.P1 80-40294 ISBN 0 08 023969 2 In order to make this volume available as economical ly and as rapidly as possible the author's typescript has been reproduced in its original form. This method has its typographical limitations but it is hoped that they in no way distract the reader. Printed in Great Britain by A. Wheat on & Co. Ltd., Exeter FOREWORD The chemistry of phosphorus in its fundamental and applied aspects has grown rapidly in the past decade. Progress has been made in nearly every scientific discipline dealing with this key element. The understanding of reaction mechanisms of organophosphorus compounds and the development of analytical tools for their studies promoted research in nucleic acid chemistry, investigations on metabolism and biosynthesis of biologically relevant phosphorus compounds and elucidation of the mode of action of enzymes responsible for their biological transformations. Although the achievements in the fields of phosphorus chemistry connected with Life Sciences are significant, still phosphorus chemistry hesi tates to open broadly towards biochemistry. International Symposia on Phosphorus Chemistry {Paris 1969, Gdansk 1974, Halle 1979) to a very low extent covered topics dealing with biological aspects of phosphorus chemistry. Remembering, that promotion of knowledge comes through interdisciplinary approaches we undertook an effort to organize an International Symposium on Phosphor