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Contributors S. A l t m a n Ephraim Katchalski Robert L . Baldwin H . Kersten B . Beltchev W . Kersten E . D . Bergmann L. S. Lerman D . F . Bradley S. Lifson Edward N . Brody Per-Olov L o w d i n A . S. V . Burgen D o n a l d B . McCormick Jacqueline Caillet Marie-José M a n t i o n e G. Cilento J. C . Metcalfe Pierre Claverie A . M . Michelson M. Cohn H. A . Nash A. Danchin Bernard Pullman J. F . Danielli K. R o s e n h e c k Robert C . D a v i s Jean Salvinien Michel D e l m e l l e Sidney Shifrin L. Dimitrijevic Meir Shinitzky Paul D o t y Oktay Sinanoglu P. D o u z o u M . A . Slifkin Jules D u c h e s n e M. N . Thang E . Peter Geiduschek H u g o Theorell M . Gilbert Ignacio T i n o c o , Jr. M . Grunberg-Manago G o r d o n Tollin Richard Harrison Paul O . P. T s ' o J. G . Heathcote Olke Uhlenbeck Karst H o o g s t e e n Gregorio Weber O. Jardetzky D a v i d L . Wilson S. Richard Jaskunas K. Zinner D . O . Jordan MOLECULAR IN ASSOCIATIONS BIOLOGY Proceedings of a n International S y m p o s i u m H e l d in Celebration of t h e 40th Anniversary of t h e Institut d e Biologie Physico-chimique (Fondation E d m o n d de Rothschild) Paris, May 8-11, 1967 Edited by BERNARD PULLMAN UNIVERSITÉ D E PARIS INSTITUT D E BIOLOGIE PHYSICO-CHIMIQUE PARIS, F R A N C E 1968 ACADEMIC PRESS New York and London C O P Y R I G H T © 1 9 6 8 , BY A C A D E M I C PRESS I N C . ALL RIGHTS RESERVED. N O PART OF THIS BOOK MAY BE R E P R O D U C E D I N A N Y FORM, BY PHOTOSTAT, MICROFILM, OR A N Y OTHER MEANS, W I T H O U T W R I T T E N PERMISSION FROM THE PUBLISHERS. ACADEMIC PRESS INC. 111 Fifth Avenue, N e w York, N e w York 10003 United Kingdom Edition published by ACADEMIC PRESS INC. (LONDON) Berkeley Square House, London W . 1 LTD. L I B R A R Y OF C O N G R E S S C A T A L O G C A R D N U M B E R : P R I N T E D IN THE U N I T E D STATES OF AMERICA 68-18679 List of Contributors N u m b e r s in parentheses indicate the pages o n which the authors' contributions begin. S. A l t m a n 1 (271), D e p a r t m e n t o f B i o p h y s i c s , U n i v e r s i t y o f C o l o r a d o S c h o o l of Medicine, Denver, C o l o r a d o R o b e r t L . B a l d w i n (145), D e p a r t m e n t o f B i o c h e m i s t r y , S t a n f o r d U n i v e r s i t y School of Medicine, Palo Alto, California B. Beltchev2 (183), Service d e B i o c h i m i e , I n s t i t u t d e Biologie Physico- chimique, Paris, France E . D . B e r g m a n n (207), D e p a r t m e n t o f O r g a n i c C h e m i s t r y , H e b r e w U n i v e r s i t y , Jerusalem, Israel D . F . Bradley (137, 261), L a b o r a t o r y of N e u r o c h e m i s t r y , N a t i o n a l Institute of M e n t a l Health, Bethesda, M a r y l a n d E d w a r d N . B r o d y (163), D e p a r t m e n t o f B i o p h y s i c s , U n i v e r s i t y o f C h i c a g o , C h i c a g o , Illinois A . S. V . B u r g e n (487), H a r v a r d M e d i c a l S c h o o l , B o s t o n , M a s s a c h u s e t t s J a c q u e l i n e C a i l l e t (217), Service d e B i o c h i m i e T h é o r i q u e , I n s t i t u t d e B i o l o g i e Physico-chimique, Paris, France G . C i l e n t o (309), D e p a r t a m e n t o d e Q u i m i c