E-Book Overview
Edited by the world leaders in this emerging field, this three-volume handbook is designed to become the landmark reference on this exciting new branch of chemistry and biology. Following an introductory section, the authors discuss the use of small molecules to explore biology, discovering small molecule probes for biological mechanisms and expanding the scope of chemical synthesis. Further sections cover chemical informatics, drug discovery and systems biology, and the whole work is rounded off by the outlook and perspectives for this field. No academic institution or pharmaceutical company can possibly miss out on this highly authoritative work.
Content: Chapter 1 Chemistry and Biology — Historical and Philosophical Aspects (pages 3–67): Gerhard Quinkert, Holger Wallmeier, Norbert Windhab and Dietmar ReichertChapter 2 Using Small Molecules to Unravel Biological Mechanisms (pages 71–94): Michael A. Lampson and Tarun M. KapoorChapter 2 Using Natural Products to Unravel Cell Biology (pages 95–114): Jonathan D. Gough and Craig M. CrewsChapter 3 Revealing Biological Specificity by Engineering Protein?Ligand Interactions (pages 115–139): Matthew D. Simon and Kevan M. ShokatChapter 3 Controlling Protein Function by Caged Compounds (pages 140–173): Andrea Giordano, Sirus Zarbakhsh and Carsten SchultzChapter 3 Engineering Control Over Protein Function; Transcription Control by Small Molecules (pages 174–197): John T. KohChapter 4 Chemical Complementation: Bringing the Power of Genetics to Chemistry (pages 199–226): Pamela Peralta?Yahya and Virginia W. CornishChapter 4 Controlling Protein–Protein Interactions Using Chemical Inducers and Disrupters of Dimerization (pages 227–249): Tim ClacksonChapter 4 Protein Secondary Structure Mimetics as Modulators of Protein–Protein and Protein?Ligand Interactions (pages 250–269): Hang Yin and Andrew D. HamiltonChapter 5 Synthetic Expansion of the Central Dogma (pages 271–295): Masahiko SisidoChapter 6 Forward Chemical Genetics (pages 299–354): Stephen J. Haggarty and Stuart L. SchreiberChapter 7 Reverse Chemical Genetics – An Important Strategy for the Study of Protein Function in Chemical Biology and Drug Discovery (pages 355–384): Rolf Breinbauer, Alexander Hillisch and Herbert WaldmannChapter 7 Chemical Biology and Enzymology: Protein Phosphorylation as a Case Study (pages 385–402): Philip A. ColeChapter 7 Chemical Strategies for Activity?based Proteomics (pages 403–426): Nadim Jessani and Benjamin F. CravattChapter 8 The Biarsenical?tetracysteine Protein Tag: Chemistry and Biological Applications (pages 427–457): Stephen R. AdamsChapter 8 Chemical Approaches to Exploit Fusion Proteins for Functional Studies (pages 458–479): Anke Arnold, India Sielaff, Nils Johnsson and Kai JohnssonChapter 9 Diversity?oriented Synthesis (pages 483–518): Derek S. TanChapter 9 Combinatorial Biosynthesis of Polyketides and Nonribosomal Peptides (pages 519–536): Nathan A. Schnarr and Chaitan KhoslaChapter 10 Expressed Protein Ligation (pages 537–566): Matthew R. Pratt and Tom W. MuirChapter 10 Chemical Synthesis of Proteins and Large Bioconjugates (pages 567–592): Philip DawsonChapter 10 New Methods for Protein Bioconjugation (pages 593–634): Matthew B. FrancisChapter 11 The Search for Chemical Probes to Illuminate Carbohydrate Function (pages 635–667): Laura L. Kiessling and Erin E. CarlsonChapter 11 Chemical Glycomics as Basis for Drug Discovery (pages 668–691): Daniel B. Werz and Peter H. SeebergerChapter 12 The Bicyclic Depsipeptide Family of Histone Deacetylase Inhibitors (pages 693–720): Paul A. Townsend, Simon J. Crabb, Sean M. Davidson, Peter W. M. Johnson, Graham Packham and Arasu GanesanChapter 13 Chemical Informatics (pages 723–759): Paul A. ClemonsChapter 13 WOMBAT and WOMBAT?PK: Bioactivity Databases for Lead and Drug Discovery (pages 760–786):