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This book introduces a number of cutting edge statistical methods which can be used for the analysis of genomic, proteomic and metabolomic data sets. In particular in the field of systems biology, researchers are trying to analyze as much data as possible in a given biological system (such as a cell or an organ). The appropriate statistical evaluation of these large scale data is critical for the correct interpretation and different experimental approaches require different approaches for the statistical analysis of these data. This book is written by biostatisticians and mathematicians but aimed at experimental researcher as well as computational biologists who often lack an appropriate background in statistical analysis.
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Edited by Matthias Dehmer, Frank Emmert-Streib Armin Graber, and Armindo Salvador Applied Statistics for Network Biology Related Titles Emmert-Streib, F., Dehmer, M. (eds.) Medical Biostatistics for Complex Diseases 2010 ISBN: 978-3-527-32585-6 Dehmer, M., Emmert-Streib, F. (eds.) Analysis of Complex Networks From Biology to Linguistics 2009 ISBN: 978-3-527-32345-6 Emmert-Streib, F., Dehmer, M. (eds.) Analysis of Microarray Data A Network-Based Approach 2008 ISBN: 978-3-527-31822-3 Junker, B. H., Schreiber, F. Analysis of Biological Networks 2008 ISBN: 978-0-470-04144-4 Stolovitzky, G., Califano, A. (eds.) Reverse Engineering Biological Networks Opportunities and Challenges in Computational Methods for Pathway Inference 2007 ISBN: 978-1-57331-689-7 Quantitative and Network Biology Series Editors M. Dehmer and F. Emmert-Streib Volume 1 Applied Statistics for Network Biology Methods in Systems Biology Edited by Matthias Dehmer, Frank Emmert-Streib, Armin Graber, and Armindo Salvador The Editors Matthias Dehmer UMIT Institute for Bioinformatics and Translational Research Eduard Wallnöfer Zentrum 1 6060 Hall, Tyrol Austria Frank Emmert-Streib Queen s University Belfast Center for Cancer Research and Cell Biology 97, Lisburn Road Belfast BT9 7BL United Kingdom Armin Graber UMIT Institute for Bioinformatics and Translational Research Eduard Wallnöfer Zentrum 1 6060 Hall, Tyrol Austria and Novartis Pharmaceuticals Corporation Oncology Biomarkers and Imaging One Health Plaza East Hanover, NJ 07936 USA Armindo Salvador University of Coimbra Center for Neuroscience and Cell Biology, Department of Chemistry 3004-535 Coimbra Portugal Composition Thomson Digital, Noida, India Printing and Binding betz-druck GmbH, Darmstadt Cover Design Adam Design, Weinheim Limit of Liability/Disclaimer of Warranty: While the publisher and author have used their best efforts in preparing this book, they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. No warranty can be created or extended by sales representatives or written sales materials. The Advice and strategies contained herein may not be suitable for your situation. You should consult with a professional where appropriate. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages. Library of Congress Card No.: applied for British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library. Bibliographic information published by the Deutsche Nationalbibliothek The Deutsche Nationalbibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data are available on the Internet at http://dnb.d-nb.de. # 2011 Wiley-VCH Verlag & Co. KGaA, Boschstr. 12, 69469 Weinheim, Germany Wiley