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General and Synthetic Methods Volume 16 A Specialist Periodical Report General and Synthetic Methods Volume 16 A Review of the Literature Published between January 1991 and July 1992 Senior Reporter G. Pattenden, Department of Chemistry, University of Nottingham Reporters R.P.C. Cousins, Glaxo Group Research, Greenford, Middx. L.P. Crawford, SmithKline Beecham, Welwyn, Herts. T . Harrison, Merck Sharpe & Dohme, Harlow, Essex D.C. Harrowven, University of Nottingham M.J. Kiefel, University of Nottingham J.D. Kilburn, University of Southampton C.F. Marcos, Imperial College of Science, Technology and Medicine, London S. Perrio, Imperial College, London 0. Riant, lmperial College, London S.K. Richardson, Notre Dame University, Notre Dame, Indiana, USA G.M. Robertson, Glaxo Group Research, Ware, Herts. J. Steele, Pfizer Central Research, Sandwich, Kent S.D.A. Street, Pfizer Central Research, Sandwich, Kent J.B. Sweeney, University of Bristol S.E. Thomas, Imperial College of Science, Technology and Medicine, London M . Wills, University of Bath SOCIETY OF CHEMISTRY ISBN 0-85186-834-7 ISSN 0141-2140 0The Royal Society of Chemistry 1994 A l l Rights Reserved N o part of this book may be reproduced or transmitted in any f o r m or b y any means -graphic, electronic, including photocopying, recording, taping, or information storage and retrieval systems - without written permission f r o m The Royal Society of Chemistry Published by The Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge CB4 4WF Printed in Great Britain by Athenaeum Press Ltd, Newcastle upon Tyne In trod uction This sixteenth Report will be the last Volume in the RSC's Specialist Periodical Report series of General arid Syrithetic Methods. Volume 16 covers the literature published over the period January 1991-July 1992, except for the chapter on "Carboxylic Acids and Derivatives" which provides coverage of the literature throughout 1990 and 1991 only. Starting in January 1994, the new RSC review journal Contemporary Organic Synthesis will act as a natural successor to Getieral arid Sytirhetic Methods, and the journal will cover all the regular literature that has been included in the Specialist Periodical Report. There will be complete continuity of coverage between the two publications over the first few years, but Coritenipoiuiy Oipmic Synthesis also aims to provide a more extended coverage of the literature of synthesis on a more regular basis and with minimum delays in publication. Contemporary Organic Syrithesis will review and provide perspective on all aspects of methodology, selectivity and efficiency in contemporary synthesis. As well as covering all the principles and methods in functional group chemistry and interconversions,organomstallic chemistry and asymmetric synthesis will feature prominently, as will modern aspects of strategy and computer-aided design, biotransformations and protecting group protocols. Special methods and techniques, such as sonochemistry, FVP, electroorganic synthesis, and supported catalysis will be included as occasional articles, and the manner in which synthesis addresses problems and provides solutions in biology, medicine, agriculture and new materials will also be encompassed. The new Join-rid will contain a number of "key features". It will: provide regular, up-to-date coverage of all major functional group interconversions - highlighting the best methods and making meaningful comparisons. add