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Hypoxia is and remains a major public health issue in many populated mountainous areas all over the world. This book is directly derived from a NATO-sponsored international meeting on problems of high altitude medicine and biology, which was held on the shores of lake Issyk-Kul, in Kyrghyzstan, in 2006. Overall, the meeting was an ideal mix of cell biology, integrative physiology and medical applications.
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Problems of High Altitude Medicine and Biology NATO Science for Peace and Security Series This Series presents the results of scientific meetings supported under the NATO Programme: Science for Peace and Security (SPS). The NATO SPS Programme supports meetings in the following Key Priority areas: (1) Defence Against Terrorism; (2) Countering other Threats to Security and (3) NATO, Partner and Mediterranean Dialogue Country Priorities. The types of meeting supported are generally "Advanced Study Institutes" and "Advanced Research Workshops". The NATO SPS Series collects together the results of these meetings. The meetings are coorganized by scientists from NATO countries and scientists from NATO's "Partner" or "Mediterranean Dialogue" countries. The observations and recommendations made at the meetings, as well as the contents of the volumes in the Series, reflect those of participants and contributors only; they should not necessarily be regarded as reflecting NATO views or policy. Advanced Study Institutes (ASI) are high-level tutorial courses intended to convey the latest developments in a subject to an advanced-level audience Advanced Research Workshops (ARW) are expert meetings where an intense but informal exchange of views at the frontiers of a subject aims at identifying directions for future action Following a transformation of the programme in 2006 the Series has been re-named and re-organised. Recent volumes on topics not related to security, which result from meetings supported under the programme earlier, may be found in the NATO Science Series. The Series is published by IOS Press, Amsterdam, and Springer, Dordrecht, in conjunction with the NATO Public Diplomacy Division. Sub-Series A. B. C. D. E. Chemistry and Biology Physics and Biophysics Environmental Security Information and Communication Security Human and Societal Dynamics http://www.nato.int/science http://www.springer.com http://www.iospress.nl Series A: Chemistry and Biology Springer Springer Springer IOS Press IOS Press Problems of High Altitude Medicine and Biology Edited by Almaz Aldashev Kirghiz Institute of Cardiology, Bishkek, Kyrgyz Republic Robert Naeije Free University of Brussels, Belgium Proceedings of the NATO Advanced Research Workshop on Problems of High Altitude Medicine and Biology Issyk-Kul, Kyrgyz Republic 5–6 June 2006 A C.I.P. Catalogue record for this book is available from the Library of Congress. ISBN 978-1-4020-6298-8 (HB) ISBN 978-1-4020-6299-5 (PB) ISBN 978-1-4020-6300-8 (e-book) Published by Springer, P.O. Box 17, 3300 AA Dordrecht, The Netherlands. www.springer.com Printed on acid-free paper All Rights Reserved © 2007 Springer No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form-or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. CONTENTS CHAPTER 1. INTRODUCTION: 45 YEARS OF MOUNTAIN MEDICINE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 James S. Milledge CHAPTER 2. HIGH ALTITUDE PULMONARY HYPERTENSION AND CHRONIC MOUNTAIN SICKNESS - REAPPRAISAL OF THE CONSE