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This first guide devoted to this burgeoning topic, this authoritative reference presents the current understanding of the phenomenon of aseptic loosening of total joint replacements from the molecular and cellular mechanisms of periprosthetic bone loss to the clinical presentation and management strategies-reviewing the properties of ceramic, metal, and polymer materials used in the replacement of joints, as well as current research on bone remodeling, wear resistance, the long-term care of implants, and emerging developments in gene therapy and tissue engineering.
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Joint Replacement and Bone Resorption DK4398_FM.indd 1 Process CyanProcess CyanProcess Magenta MagentaProcess Process Yellow YellowProcess Process Black 9/14/05 10:32:23 AM Joint Replacement and Bone Resorption Pathology, Biomaterials, and Clinical Practice Edited by Arun Shanbhag Massachusetts General Hospital Harvard Medical School Boston, Massachusetts, U.S.A. Harry E. Rubash Massachusetts General Hospital Harvard Medical School Boston, Massachusetts, U.S.A. Joshua J. Jacobs Rush University Medical Center Chicago, Illinois, U.S.A. DK4398_FM.indd 2 Process CyanProcess CyanProcess Magenta MagentaProcess Process Yellow YellowProcess Process Black 9/14/05 10:32:24 AM DK4398_Discl.fm Page 1 Monday, September 26, 2005 9:33 AM Published in 2006 by Taylor & Francis Group 270 Madison Avenue New York, NY 10016 © 2006 by Taylor & Francis Group, LLC No claim to original U.S. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number-10: 0-8247-2954-4 (Hardcover) International Standard Book Number-13: 978-0-8247-2954-7 (Hardcover) This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. No part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC) 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging-in-Publication Data Catalog record is available from the Library of Congress Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com Taylor & Francis Group is the Academic Division of Informa plc. To Ganesha God of Beginnings, Remover of Obstacles. By His grace All is done. To my parents and extended family for developing and strengthening the foundations of my internal lodestone and awakening my intellectual curiosity. Also to my wife, Manashi, for her generous kindness, extraordinary patience and loving support. Arun Shanbhag To Brad, for your strength of character, maturity and humor. Best wishes for success, personal and collegiate; Steven, for your