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A range of medical and biological sciences, including occupational health and pharmacology are represented by the contributors. They review issues of molecular and cellular biology as well as clinical aspects of environmental oxidants and their effects on target organs. After looking at the basic pathology induced by pro-oxidant environmental xenobiotic they consider lungs, skin, and eyes as target organs of environmental oxidants. Among specific topics are the role of oxidative stress in chemical carcinogenesis, cigarette smoking and pulmonary oxidative damage, ozone stress in the skin barrier, and the role of ocular free radicals in age-related macular degeneration.
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This Page Intentionally Left Blank ISBN: 0-8247-0530-0 This book is printed on acid-free paper. Headquarters Marcel Dekker, Inc. 270 Madison Avenue, New York, NY 10016 tel: 212-696-9000; fax: 212-685-4540 Eastern Hemisphere Distribution Marcel Dekker AG Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland tel: 41-61-261-8482; fax: 41-61-261-8896 World Wide Web http:/ /www.dekker.com The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Copyright 2001 by Marcel Dekker, Inc. All Rights Reserved. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Current printing (last digit): 10 9 8 7 6 5 4 3 2 1 PRINTED IN THE UNITED STATES OF AMERICA Series Introduction Oxygen is a dangerous friend. Overwhelming evidence indicates that oxidative stress can lead to cell and tissue injury. However, the same free radicals that are generated dur