Vitamins & Hormones Volume 85, 2-349 (2011) Activins and Inhibins Edited by: Gerald Litwack ISBN: 978-0-12-385961-7 Series Editors Copyright Contributors Preface Gerald Litwack Chapter One - Activin Receptor-Like Kinase and the Insulin Gene Rie Watanabe Chapter Two - Crystal Structure of Activin Receptor Type IIB Kinase Domain Seungil Han Chapter Three - Activin/Nodal Signaling and Pluripotency Zhenzhi Chng, Ludovic Vallier, Roger Pedersen Chapter Four - Intracrine Signaling Mechanisms of Activin A and TGF-β Olav A. Gressner Chapter Five - Negative Regulation of Activin Signal Transduction Sun-Cheol Choi, Jin-Kwan Han Chapter Six - Antagonism of Activin by Activin Chimeras Uwe Muenster, Radhika Korupolu, Ratindra Rastogi, Jessica Read, Wolfgang H. Fischer Chapter Seven - Activins and Cell Migration Hong-Yo Kang, Chih-Rong Shyr Chapter Eight - The Synthesis and Secretion of Inhibins Kelly L. Walton, Yogeshwar Makanji, David M. Robertson, Craig A. Harrison Chapter Nine - Multifunctional Roles of Activins in the Brain Hiroshi Ageta, Kunihiro Tsuchida Chapter Ten - The Role of Activin/Nodal and Wnt Signaling in Endoderm Formation Catherine Payne, Jason King, David Hay Chapter Eleven - Activin in Glucose Metabolism Osamu Hashimoto, Masayuki Funaba Chapter Twelve - Activin in Humoral Immune Responses Kenji Ogawa, Masayuki Funaba Chapter Thirteen - The Regulation and Functions of Activin and Follistatin in Inflammation and Immunity Mark P. Hedger, Wendy R. Winnall, David J. Phillips, David M. de Kretser Chapter Fourteen - Feedback Regulation by Inhibins A and B of the Pituitary Secretion of Follicle-Stimulating Hormone Yogeshwar Makanji, Craig A. Harrison, David M. Robertson Chapter Fifteen - Activin A in Nonalcoholic Fatty Liver Disease Arne Yndestad, John Willy Haukeland, Tuva B. Dahl, Bente Halvorsen, Pål Aukrust Subject Index ii iv xiii-xv xvii-xviii 1-27 29-38 39-58 59-77 79-104 105-128 129-148 149-184 185-206 207-216 217-234 235-253 255-297 299-321 323-342 343-349 Former Editors ROBERT S. HARRIS KENNETH V. THIMANN Newton, Massachusetts University of California Santa Cruz, California JOHN A. LORRAINE University of Edinburgh Edinburgh, Scotland PAUL L. MUNSON University of North Carolina Chapel Hill, North Carolina JOHN GLOVER University of Liverpool Liverpool, England GERALD D. AURBACH Metabolic Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda, Maryland IRA G. WOOL University of Chicago Chicago, Illinois EGON DICZFALUSY Karolinska Sjukhuset Stockholm, Sweden ROBERT OLSEN School of Medicine State University of New York at Stony Brook Stony Brook, New York DONALD B. MCCORMICK Department of Biochemistry Emory University School of Medicine, Atlanta, Georgia Cover photo credit: Han, S. Crystal structure of activin receptor type IIB kinase domain. Vitamins and Hormones (2011) 85, pp. 29–38. Academic Press is an imprint of Elsevier 32 Jamestown Road, London, NW1 7BY, UK Radarweg 29, PO Box 211, 1000 AE Amsterdam, The Netherlands Linacre House, Jordan Hill, Oxford OX2 8DP, UK 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA First edition 2011 Copyright # 2011 Elsevier Inc. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone (+44) (0) 1865 843830; fax (+44) (0) 1865 853333; email: