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Explores current and emerging applications of microbes as cancer-fighting agentsToday, treatment options for cancer patients typically include surgery, radiation therapy, immunotherapy, and chemotherapy. While these therapies have saved lives and reduced pain and suffering, cancer still takes millions of lives every year around the world. In recent years, researchers have been working on a new strategy: developing microbes and microbial products that specifically attack cancer cells.This book breaks new ground in emerging cancer treatment modalities by presenting recent advances in the use of microorganisms and viruses as well as their products in cancer therapy. Seventeen chapters review the application of live microorganisms, high and low molecular weight products derived from microorganisms, and microbial products fused to cancer-targeting molecules. In addition, the book highlights the benefits of a multi-target approach to destroy cancer cells. Readers will not only discover the results and significance of basic and clinical research, but also encouraging results from clinical trials.Emerging Cancer Therapy is divided into three sections:Section 1: Live/Attenuated Bacteria and Viruses as Anticancer AgentsSection 2: Bacterial Products as Anticancer AgentsSection 3: Patents on Bacteria/Bacterial Products as Anticancer AgentsWith chapters written by leading pioneers in microbial, biotech, and cancer research, Emerging Cancer Therapy is recommended for biotechnologists, microbiologists, clinical oncologists, medicinal chemists, and biochemists. Readers will not only learn the tremendous potential of microbial and biotechnological approaches to cancer therapy, but also discover new directions of research for effective drug discovery and development.
E-Book Content
EMERGING CANCER THERAPY Microbial Approaches and Biotechnological Tools Edited by ARSÉNIO M. FIALHO ANANDA M. CHAKRABARTY A JOHN WILEY & SONS, INC., PUBLICATION EMERGING CANCER THERAPY Wiley Series in BIOTECHNOLOGY AND BIOENGINEERING Significant advancements in the fields of biology, chemistry, and related disciplines have led to a barrage of major accomplishments in the field of biotechnology. The Wiley Series in Biotechnology and Bioengineering will focus on showcasing these advances in the form of timely, cutting-edge textbooks and reference books that provide a thorough treatment of each respective topic. Topics of interest to this series include, but are not limited to, protein expression and processing; nanotechnology; molecular engineering and computational biology; environmental sciences; food biotechnology, genomics, proteomics, and metabolomics; large-scale manufacturing and commercialization of human therapeutics; biomaterials and biosensors; and regenerative medicine. We expect these publications to be of significant interest to practitioners both in academia and industry. Authors and editors were carefully selected for their recognized expertise and their contributions to the various and farreaching fields of biotechnology. The upcoming volumes will attest to the importance and quality of books in this series. I would like to acknowledge the fellow co-editors and authors of these books for their agreement to participate in this endeavor. Lastly. I would like to thank Ms. Anita Lekhwani, Senior Acquisitions Editor at John Wiley & Sons, Inc. for approaching me to develop such a series. Together, we are confident that these books will be useful additions to the literature that will not only serve the biotechnology community with sound scientific knowledge, but also with inspiration as they further chart the course in this exciting field. Anurag S. Rathore Amgen Inc. Thousand Oaks, CA, USA Titles in series Quality by Design for Biopharmaceuticals: Principles and Case Studies / Edited by Anurag S. Rathore and Rohin Mhatre Emer