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The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia. Key Features* Detailed insights into viral packaging, expression, and assembly* Mechanistic understanding of how HIV interacts with receptors and infects cells* Delineation of virally encoded regulatory processes unique to HIV* Clinical Applications:* An updated review of current chemotherapeutics for HIV* New concepts in the discovery and design of novel anti-HIV drugs* The latest developments in HIV-vaccine research
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HIV-1: MOLECULAR BIOLOGY AND PATHOGENESIS CLINICAL APPLICATIONS SERIAL EDITORS J. Thomas August Ferid Murad Baltimore, Maryland Houston, Texas ADVISORY BOARD R. Wayne Alexander Floyd E. Bloom Boston, Massachusetts La Jolla, California Thomas F. Burke Leroy Liu Houston, Texas Piscataway, New Jersey Anthony R. Means G. Alan Robison Durham, North Carolina Houston, Texas John A. Thomas Thomas C. Westfall San Antonio, Texas St. Louis, Missouri HIV-1: MOLECULAR BIOLOGY AND PATHOGENESIS CLINICAL APPLICATIONS The Second of a Two-Volume Set Edited by Kuan-Teh Jeang Laboratory of Molecular Biology NIAID/NIH Bethesda, Maryland ADVANCES IN PHARMACOLOGY VOLUME 49 San Diego San Francisco New York Boston London Sydney Tokyo This book is printed o n acid-free paper. @ Copyright 0 2000 by ACADEMIC PRESS All Rights Reserved. No oalt of this oublication mav be reoroduced or transmitted in anv form or bv. anv. mean,, cleitronic .,r mechan~;al, lncludlng phoh,a,p). recurding, or an) inf,xrnation sulragc and rctrirvd r),tcm, ~ t t h u u pcrm~rr!.,n t in urltmg iron) the Publ~rhcr The appearance of the code at the bottom ofthe first page of a chapter in this book indicates the Publisher's consent that cooies ofthe chaoter mav be made for pcnlml tlr intrrnd u\c uf spc:ifii :l~cn;c ~ h lcosscn'l j is ptvett on lhc cond~l~on, ho%ss\sr.that ths coplsr pa! the jtated psr copy ice through the Copyright C'lcsmncc Center, Inc. (222 Rosewood Drive, Danvers, Massachusetts 01923), for copying beyond that ~ermittedby Sections 107 or 108 of the U.S. Copyright Law. This consent dois not extend to otheFkinds of coovine. . . .. such as couvine .. - fo; -eeneral disuibution. for advsnlslne or promol~onalpurposes, ior crcalng ncn collective norks, or tor rc.iale. Copy tkcs tor prc-2000 chapter, arc a, ,haan on ihe title pilpui. If m, fee cade appears on the title page, the copy fee is the same ar for current chapters. 1054-3589100 $35.00 . Exulicit Demission from Academic Press is not reauired to reoroduce a maximum of , nro tigure. or tahler from an .A;aJcmic Prcqr chapter in another rrirnlific or rcrcuch puhlicatiun pro, idcd i h ~ the t materid ha, n.81 hccn ~ r c d i c d1.) mm,thcr wurcc m J that full credit