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This volume features contributions from participants of the ESRF symposium on "Immunotherapy in 2020—Visions and Trends for Targeting Inflammatory Diseases" held in Potsdam near Berlin, Germany, in October 2006. The symposium presentations covered the main mechanisms of immunoregulation such as peripheral and central tolerance, epigenetic programming, immunologic memory, and regulatory networks in inflammation as well as novel experimental and clinical approaches for targeting inflammation in autoimmunity and transplantation. An important related question is how recent findings in immunological research can lead to improved diagnostics, new drugs, and better therapies. The targeting of novel pathways and immunoregulatory mechanisms, the challenge of immunologic memory for lastingly successful anti-inflammatory therapy, new approaches for adoptive T cell and polyclonal antibody therapies, and the individualization of immunomodulatory therapies are thereby topics of this volume.
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Ernst Schering Foundation Symposium Proceedings 2006-4 Immunotherapy in 2020 Ernst Schering Foundation Symposium Proceedings 2006-4 Immunotherapy in 2020 Visions and Trends for Targeting Inflammatory Disease A. Radbruch, H.-D. Volk, K. Asadullah, W.-D. Doecke Editors With 10 Figures 123 Series Editors: G. Stock and M. Lessl Library of Congress Control Number: 2007928116 ISSN 0947-6075 ISBN 978-3-540-70850-6 Springer Berlin Heidelberg New York This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2007 The use of general descriptive names, registered names, trademarks, etc. in this publication does not emply, even in the absence of a specific statemant, that such names are exempt from the relevant protective laws and regulations and therefor free for general use. Product liability: The publisher cannot guarantee the accuracy any information about dosage and application contained in this book. In every induvidual case the user must check such information by consulting the relevant literature. Editor: Dr. Ute Heilmann, Heidelberg Desk Editor: Wilma McHugh, Heidelberg Production Editor: Martin Weißgerber, Leipzig Cover design: design & production, Heidelberg Typesetting and production: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig 21/3180/YL – 5 4 3 2 1 0 Printed on acid-free paper Preface From 22 to 24 October 2006, internationally renowned scientists from the European Union and the United States met in Potsdam near Berlin, Germany, to discuss the future of chronic inflammatory disease treatment. The title of the symposium, organized by the Ernst Schering Foundation, was “Immunotherapy in 2020—Visions and Trends for Targeting Inflammatory Diseases”. The presentations covered the main mechanisms of immunoregulation such as peripheral and central tolerance, epigenetic programming, immunologic memory, and regulatory networks in inflammation as well as novel experimental and clinical approaches for targeting inflammation in autoimmunity and transplantation. Group discussions focused on the question of how recent findings in immunological research can lead to improved diagnostics, new drugs, and better therapies. In this regard, beside novel approaches, the i