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This volume contains reviews highlighting some of the most important achievements in understanding the molecular basis of cancer. Included are reviews on human papilloma virus and tumor suppressor gene products, the function of SH2 and SH3 domains in tyrosine kinase signal transduction, oncogene activation in mammary tumors, the phenotypes of polyoma middle T antigen in transgenic animals, and the role of protein kinase C and FCg receptors in neoplastic disease. Transgenic animal models for the study of molecular events in cancer are especially featured in these reviews. * Highlights of Volume 64:* Interactions of papilloma virus proteins with tumor suppressors* Retinoblastoma tumor suppressor protein* SH2 and SH3 domains in tyrosing kinase signal transduction* Oncogene activation in mammary tumors* Polyomavirus middle T antigen phenotypes in transgenic animals* Protein kinase C and FCg receptors in neoplastic disease* Transgenic mouse models for molecular carcinogenesis
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ADVANCES IN CANCER RESEARCH VOLUME 64 This Page Intentionally Left Blank ADVANCES IN CANCERRESEARCH Edited by GEORGE F. VANDE WOUDE ABL-Basic Research Program NCI-Frederick Cancer Research and Development Center Frederick, Maryland GEORGE KLElN Department of Tumor Biology Karolinska lnstitutet Stockholm, Sweden Volume 64 ACADEMIC PRESS w San Diego New York Boston London Sydney Tokyo Toronto This book is printed on acid-free paper. @ Copyright 8 1994 by ACADEMIC PRESS, INC. All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Academic Press, Inc. A Division of Harcourt Brace & Company 525 B Street, Suite 1900, San Diego, California 92101-4495 (Jnired Kingdom Edition published b.v Academic Press Limited 24-28 Oval Road, London NWI 7DX International Standard Serial Number: 0065-230X International Standard Book Number: 0-12-006664-5 PRINTED IN THE UNITED STATES OF AMERICA 94 95 9 6 9 1 98 9 9 Q W 9 8 7 6 5 4 3 2 1 CONTENTS ix CONTRIBUTORS TO VOLUME 64 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Interactions between Papillomavirus Proteins and Tumor Suppressor Gene Products KAREN H. VOUSDEN I. 11. 111. IV. V. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Human Papillomaviruses ............. Regulation of Cell Growth . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . ViraUHost Protein Interactions HPV Oncoproteins-Tools and ............................. References ...................... . . . . . . . . . . . . . . . . . . . . . . 1 2 5 7 18 19 The Retinoblastoma Tumor Suppressor Protein JEANY. J. WANG,ERIKS. KNUDSEN, AND PETER J. WELCH I. 11. 111. IV. V. VI. VII. Overview ........................... . . . . . . . . . . . . . . . . . . . . . . Mutation o .... .................. Growth-Inhibitory Activity of RB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cell Cycle-Regulated Phosphorylation of RB Protein-Binding Function of RB ................................... Regulation of RII Function by Phosphorylation ..................... Future Prospects ................................................. References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V 25 26 30 32 48 70 75 78 CONTENTS SH2 and SH3 Domains in Signal Transduction TONY PAWSON Protein 'I'\rosine Kin