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ADVANCES IN CANCER RESEARCH VOLUME 53 This Page Intentionally Left Blank ADVANCES IN CANCER RESEARCH Edited by GEORGE F. VANDE WOUDE NCI-Frederick Cancer Research Facility Frederick, Maryland GEORGE KLEIN Department of Tumor Biology Karolinska lnstitutet Stockholm, Sweden Volume 53 ACADEMIC PRESS, INC. Harcourt Brace Jovanovlch, Publirhers San Diego New York Berkeley Boston London Sydney Tokyo Toronto COPYRIGHT 0 1989 BY ACADEMIC PRESS, INC. All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. ACADEMIC PRESS, INC. San Diego, California 92101 United Kingdom Edition published hq ACADEMIC PRESS LIMITED 24-28 Oval Road, London NWI 7DX LIBRARY OF CONGRESS CATALOG CARD NUMBER: ISBN 0-12-006653-X (alk. paper) PRINTED IN THE UNITED STATES OF AMERICA 89909192 9 8 1 6 5 4 3 2 1 52-13360 CONTENTS CONTRIBUTORS TO VOLUME5 3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix Serum-inducible Genes BARRETTJ. ROLLINS AND CHARLES D. STILES I. Introduction .................. 11. History: The .......................... 111. Biochemistry: The Role of Transcription and Translation in the Mitogenic Response to Serum .............. IV. Molecular Biology: Serum-Inducible Genes and Their Products . . . . . . . . . . . . . . V. Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . VI. Addendum.. . . . . . . .... ................ References . . . . . . . . .... ................ 1 3 5 8 21 22 25 Malaria, Epstein-Barr Virus, and the Genesis of Lymphomas CHRISTINE I. 11. 111. IV. V. A. FACER AND J. H.L. PLAYFAIR Introduction ................................ The Epstein-Barr Virus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Burkitt’s Lymphoma Malaria . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Malaria and the Immune System ............................... 34 46 68 A Review of Kaposi’s Sarcoma JANE I. 11. 111. IV. ARMES Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Clinical Features and Epidemiology of Kaposi’s Sarcoma ..................... Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cell of Origin of KS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V 73 73 76 76 vi CONTENTS Neoplasm or Hyperplasia? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V. KS . VI . Etiology of KS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . VII . Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 80 85 85 The Relationship between MHC Antigen Expression and Metastasis JACOB GOPAS.BRACHARAGER.ZISMAN. MENASHEBAR.ELI. GUNTERJ . HAMMERLING. AND SHRAGA SEGAL 89 I . Introduction . .