Vegetables, Whole Grains and their Derivatives in Cancer Prevention looks in detail at the evidence regarding the effects and mechanisms of action of potentially cancer-preventive components and their sources from plant kingdom. The book covers current knowledge on certain foods and their constituents in cancer prevention, such as cruciferous and green leafy vegetables, nuts and seeds, whole grains, tomato lycopene and carotenoids, alliums and their sulphur and selenium constituents, and capsaicinoids from chilli peppers. It focuses not only on single compounds but aims to widen the view by discussing a whole-diet approach in cancer prevention. A single component may lose its chemopreventive efficacy when isolated from the food matrix and in many cases isolated and concentrated components as supplements may actually induce tumor development. Apart from describing the effects and mechanisms of action, the chapters also contain information on intake, bioavailability, metabolism and possible toxic effects of foods and components presented. Evaluation and comparison of the data from mechanistic studies in vitro with those from animal experiments in vivo form a basis for applying the current knowledge to human nutrition in the field of carcinogenesis. With contributions from leading experts in the field, this book is an invaluable resource for scientists and professionals working in cancer research, as well as individuals involved in food and nutrition.
Diet and Cancer Series Editor Adriana Albini Head Oncology Research, IRCCS MultiMedica, Via Fantoli 15/16, 20138 Milano, Italy and MultiMedica Castellanza 21053 Castellanza (VA), Italy Tel. +39-02-55406532 Fax +39-02-55406503
[email protected] For further volumes: http://www.springer.com/series/8049 Marja Mutanen · Anne-Maria Pajari Editors Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention 13 Editors Marja Mutanen Department of Food and Environmental Sciences University of Helsinki Helsinki 00014, Finland
[email protected] Anne-Maria Pajari Department of Food and Environmental Sciences University of Helsinki Helsinki 00014, Finland
[email protected] ISBN 978-90-481-9799-6 e-ISBN 978-90-481-9800-9 DOI 10.1007/978-90-481-9800-9 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010936635 © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Preface This book aims to update our knowledge and increase our understanding on the field of vegetables and whole grains in cancer prevention. There is a long list of bioactive compounds available in vegetable kingdom such as vitamins, minerals, carotenoids, phytosterols, polyphenols etc., which have been intensely studied, often as pure compounds, by several research groups in the diet and cancer field. This book focuses not only on single compounds but aims to widen the view by includi