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Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.
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Polyploidization and Cancer
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research JOHN D. LAMBRIS, University of Pennsylvania RODOLFO PAOLETTI, University of Milan
Recent Volumes in this Series Volume 668 SUPERMEN1 Edited by Katalin Balogh and Attila Patocs Volume 669 NEW FRONTIERS IN RESPIRATORY CONTROL Edited by Ikuo Homma and Hiroshi Onimaru Volume 670 THERAPEUTIC APPLICATIONS OF CELL MICROENCAPSULATION Edited by José Luis Pedraz and Gorka Orive Volume 671 FRONTIERS IN BRAIN REPAIR Edited by Rahul Jandial Volume 672 BIOSURFACTANTS Edited by Ramkrishna Sen Volume 673 MODELLING PARASITE TRANSMISSION AND CONTROL Edited by Edwin Michael and Robert C. Spear Volume 674 INTEGRINS AND ION CHANNELS: MOLECULAR COMPLEXES AND SIGNALING Edited by Andrea Becchetti and Annarosa Arcangeli Volume 675 RECENT ADVANCES IN PHOTOTROPHIC PROKARYOTES Edited by Patrick C. Hallenbeck Volume 676 POLYPLOIDIZATION AND CANCER Edited by Randy Y.C. Poon
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Polyploidization and Cancer Edited by Randy Y.C. Poon, MA, PhD Department of Biochemistry, Hong Kong University of Science and Technology Clear Water Bay, Hong Kong, China
Springer Science+Business Media, LLC Landes Bioscience
Springer Science+Business Media, LLC Landes Bioscience Copyright ©2010 Landes Bioscience and Springer Science+Business Media, LLC All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission being entered and executed on a computer system; for exclusive use by the Purchaser of the work. Printed in the USA. Springer Science+Business Media, LLC, 233 Spring Street, New York, New York 10013, USA http://www.springer.com Please address all inquiries to the publishers: Landes Bioscience, 1002 West Avenue, Austin, Texas 78701, USA Phone: 512/ 637 6050; FAX: 512/ 637 6079 http://www.landesbioscience.com The chapters in this book are available in the Madame Curie Bioscience Database. http://www.landesbioscience.com/curie Polyploidization and Cancer, edited by Randy Y.C. Poon. Landes Bioscience / Springer Science+Business Media, LLC dual imprint / Springer series: Advances in Experimental Medicine and Biology. ISBN: 978-1-4419-6198-3 usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes