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For over half a century, this book has served the discipline of medicinal chemistry for both graduate and undergraduate pharmacy and chemistry students as well as practicing pharmacists. Fully updated for the Eleventh Edition, coverage begins with the fundamental principles of chemistry, biochemistry, and biology that underlie the discipline of medicinal chemistry. These principles are then applied to understanding the properties, mode of action, therapeutic applications, and limitations of various pharmaceutical agents. The subject matter is organized by pharmaceutical and therapeutic classes, providing a bridge between the basic sciences and clinical practice. The text contains many tables for quick reference to names, formulations, dosages, and applications.
E-Book Content
Wilson and Gisvold's Textbook of
ANIC MEDICINAL AND PHARMAC ICAL CHEMIS TRY E
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Wilson and Gisvold's Textbook of
ORGANIC MEDICINAL AND PHARMACEUTICAL CHEMISTRY
ELEVENTH EDITION Edited by
John H. Block, Ph.D., R.Ph. Professor of Medicinal Chemistry Department of Pharmaceutical Sciences College of Pharmacy Oregon State University Corvallis. Oregon
John M. Beale, Jr., Ph.D. Associate Professor of Medicinal Chemistry and Director of Pharmaceutical Sciences St. Louis College of Pharmacy St. Louis, Missouri
WILLIAMS
WILKINS
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The publisher is not responsible (as a matter of product liability, negligence, or otherwise) For any injury resulting from any material contained herein. This publication contains infonttation relating to general principles ui medical care that should not he construed a.s specific instructions for individual patiettts. Manuthcturers' prnduct information and package inserts should he reviewed lOr current information, including contraindicationt. dosages, and precautions. Prinle'rI in the Uniteg! Stale.s of Anwrieu
First Editton, 1949 Second Edition. 1954 Third Edition. 1956
Filth Edition. 1966 Sixth Edition. 1971 Seventh Edition, 1977
Eighth Edition. 1982 Ninth Edition, 1991 Tenth Edition, 1998
rswrtli Edition, (962
Llbrnry or Congrnas Cataloglng.In.Publkatloit Data Wilson and Gisvold's textbook of organic medicinal and phartnaccutical chemistry.— 11th ed. / edited by John H. Block. John M. Beale Jr. p.
cm,
Includes bibliographical references attd index. ISBN 11-7817-34111-9
I. Pharmaceutical chemistry. 2. Chemistry. Organic. I. Title: Textbook of organic medicinal and pharmaceutical chemistry. II. Wilson. Charles Owens. 1911—2002 10. Gisvold. Ole.
l904- IV. Block. John H. V. Ileak. John Marlowe. IDNLM: I. Chemistry. Pharmaceutical. 2. Chemistry. Organic. QV 744 W754 2ll(9J RS403. 143 2111)4
6 IS'. 19—dc2l 20031)48849
The puhlisher.s have tizade every effort to trace the c'opyri gut itolders for borrowed material. If they have inadvertently overlooked any. they will be pleased to make the n