The goal of the International Immune-Mediated Diseases: From Theory to Therapy (IMD) Congress is to bring the best world immunologists and clinicians to Moscow to participate in plenary sessions, symposia and educational workshops designed to expose basic and clinical immunologist as well as practicing clinicians to the newest developments in the field. First IMD Congress consisted of 8 Plenary Sessions, 40 Symposia and 25 Workshops. The meeting attracted almost 2000 participants and speakers from 15 countries. After this great success of the First IMD Congress, the Organizing Committee decided to convene the meeting every other year and the Second International IMD Congress was planned for September 2007. Special attention will be given to innovative therapeutic modalities, allergy and asthma, immunodeficiency, tumor and transplant immunology, immunotherapy and vaccines, HIV and infectious diseases, autoimmune diseases, inflammation, immunomonitoring and immunodiagnostics.
This volume includes contributions from the speakers of the Second IMD Congress (September 10-15, 2007; Moscow, Russia) who are eager to share some of the academic and clinical enthusiasm that defines the IMD meetings.
Immune-Mediated Diseases
Immune-Mediated Diseases From Theory to Therapy
Edited by
Michael R. Shurin Division of Clinical Immunopathology Department of Pathology University of Pittsburgh Medical Center Pittsburgh, Pennsylvania
Yuri S. Smolkin Department of Immunology Institute for Continuing Medical Education and Clinical and Research Center for Allergy and Immunology Moscow, Russia
Editors: Michael R. Shurin Associate Professor of Pathology and Immunology Associate Director, Division of Clinical Immunopathology 5725 Children’s Hospital of Pittsburgh Main Tower 200 Lothrop Street Pittsburgh, PA 15213
[email protected]
Yuri S. Smolkin Professor of Immunology Institute for Continuing Medical Education Vise-President, Russian Association of Pediatric Allergology and Immunology Director, Clinical and Research Center of Allergy and Immunology Ostrovitianova St., Bldg. 6 Moscow 117513, Russia
[email protected]
Library of Congress Control Number: 2007928315 ISBN 978-0-387-72004-3
e-ISBN 978-0-387-72005-0
Printed on acid-free paper. c 2007 Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. 9 8 7 6 5 4 3 2 1 springer.com
Contents
Preface and Acknowledgments........................................................................... ..... xi List of Contributing Speakers ...............................................................................xiii Immune-Mediated Diseases 1. Immune-Mediated Diseases: Where Do We Stand? .........................................3 Michael R. Shurin and Yuri S. Smolkin Immunodeficiencies: News and Updates 2. The Four Most Common Pediatric Immu