ADVANCES IN CANCER RESEARCH VOLUME 39 Contributors to This Volume Michael Baum Beverly E. Griffin David A. Berstock A. Marchok Thierry Boon Dorothy A. Miller Stephen M. Dilworth Orlando J. Miller Paula J. Enrietto I? Nettesheim E. Gorelik John A. Wyke ADVANCES IN CANCERRESEARCH Edited by GEORGE KLEIN Department of Tumor Biology Karolinska lnstitutet Stockholm. Sweden SIDNEY WEINHOUSE Fels Research Institute Temple University School of Medicine Philadelphia, Pennsylvania Volume 39- 1983 ACADEMIC PRESS A Subsidiary of Harcourt Brace Jovanovich, Publishers New York London Paris San Diego San Francisco Sao Paulo Sydney Tokyo Toronto COPYRIGHT @ 1983, BY ACADEMIC PRESS,INC, ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS, INC. 11 1 Fifth Avenue, New York, New York 10003 United Kingdom Edition prcblislied b y ACADEMIC PRESS, INC. (LONDON) LTD. 24/28 Oval Road, London N W l 7DX LIBRARY OF CONGRES CATALOG CARD NUMBER:52- 13360 ISBN 0-1 2-006639-4 PRINTED IN THE UNITED STATES OF AMERICA 83 84 85 86 9 8 7 6 5 4 3 2 1 CONTENTS CONTRIBUTORS TO V O L U M E 39 . . . . . . . . . . . . . . . . , . . . . , , . ix Neoplastic Development in Airway Epithelium NETTESHEIM AND A. MARCHOK 1. Introduction . . . . . . . . . . . . . . . . . . . . . . Experimental Approaclies and Methodologies. . . . . . . . 111. Morphology of Acute Phase Responses-Early Iiiduction Pliasc I\'. Chronic. Phase Hespoiises . . . . . . . . . . . . . . . . v. Crll Popiilatioii Studies during Neoplastic Development . . . VI. klodifiers of Neoplastic Developiiient in Airway Epithelium . VII. Conclusions . . . . , . . . . . . . . . . . . . . . . . 11. Kcfcrciicc,s . . . . . . . . . . . . . . . . , . . . , 1 . . , , , 4 . . . . . . . . . , . . . . . . , . . . . lh 24 44 . , , , , . . . , , , . . . . 59 62 . , . . . . . . . . . . . . . , , 63 Concomitant Tumor Immunity and the Resistance to a Second Tumor Challenge E. GORELlK Introductiorr , . . , . . . . . . . . . . . , . . . . . . . . . Tuinor Excision a d Iiesistancc to a Second Tumor Challenge: Sinecoinitant Immunity . . . . . . . . . . . , . , . . . . . . 111. Resistancc, of the Tumor-Bearing Host to a Second Tuiiior Cliiillengt: Coiicomitant Tumor Immunity . . , . . . , , . . , . . , . . . I\< metastases="" as="" a="" second="" tiunor="" grat't:="" antiilletastatic="" concomitant="" immunity="" .="" ,="" .="" .="" .="" .="" .="" .="" .="" .="" .="" .="" ,="" .="" v.="" is="" tlic-="" status="" of="" concomitant="" immunity="" l1iiiqiic="" for="" n="" tiuiior-host="" relationship?.="" .="" ,="" .="" ,="" ,="" ,="" .="" .="" .="" .="" .="" .="" .="" .="" .="" ,="" vi="" .="" mrclimisms="" of="" resistancc="" of="" tho="" tumor-rearing="" host="" to="" a="" second="" tumor="" graft.="" .="" .="" .="" .="" .="" .="" ,="" ,="" .="" .="" .="" .="" .="" .="" .="" .="" .="" .="" .="" vii.="" h4echanisms="" of="" thc="" inhibition="" of="" m="" b="" y="" tlic="" pririitiry="" tumor.="" .="" .="" .="" .="" .="" ,="" .="" ,="" ,="" .="" .="" .="" .="" .="" .="" .="" .="" .="" .="" .="" vii