Advances in CANCER RESEARCH Volume 78 This Page Intentionally Left Blank Advances in CANCER RESEARCH Volume 78 Edited by George F. Vande Woude ABL-Basic Research Program National Cancer Institute Frederick Cancer Research and Development Center Frederick, Maryland George Klein Microbiology and Tumor Biology Center Karolinska lnstitutet Stockholm, Sweden ACADEMIC PRESS San Diego London Boston New York Sydney Tokyo Toronto This book is printed on acid-fke paper. @ Copyright (4 2000 by ACADEMIC PRESS All Rights Reserved. No part of this publication may be reproducedor transmi#ed in any form or by any means,electronicor mechanical,includingphotooopy, recording, or any information storage and retrieval system, without permission in writingh n the Publisher. The appearanceof the code at the bottom of the first page of a chapter in this book indicates the Publisher’s comeat that copies of the chapter may be made for personal or internal use of specific clients. This conseat is given on the condition, however, that the copier pay the stated per copy fee through the CopyrightClearance Center, lnc. (222Rosewood Drive, Danvers, Massachusetts 01923) for copying beyond that p*mitt+d by Sections 107 or 108 ofthe U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution,for advertisingor promotional purposes, for creating new collectiveworks, or for resale. Copy fees for pre-2000chapters are as shown on the title pages. If no fee code appears on the title page, the copy fee is the same as for current chapters. 0065-23OWOO $30.00 Explicit permission iknn Academic Press is not requiredto reproduce a maximum of two figures or tables from an Academic Press chapter in another scientificor research publication provided that the material has not been credited to another source and that full credit to the Academic Press chapter is given. Academic Press A Harcourt Science and Technology Company 525 B Street,Suite 1900, San Diego, California 921014495. USA http:l/www.apnet.com Academic Press 24-28Oval Road, London NW 1 7DX UK http://www.hbuk.co.uWap/ lntemational S&dard Book Number: 0-12-006678-5 PRINTED IN THE UNITED STATES OF AMERICA 99 0001 02 03 04BB 9 8 7 6 5 4 3 2 1 Contents Contributors to Volume 78 vii Cell Transformation by the E7 Oncoprotein of Human Papillomavirus Type 16: Interactions with Nuclear and Cytoplasmic Target Proteins Werner Zwerschke a n d Pidder Jansen-Durr I. II. III. IV. Background: The Role of Papillomaviruses in Human Cancer 2 Cellular E7-Binding Proteins 6 Modulation of Cellular Functions by E7 9 The Role of HPV-16 E7 in Cell Proliferation and Immortalization 17 References 22 Tumor Invasion: Role of Growth FactoFlnduced Cell Motility Alan Wells I. Introduction 32 II. Tumor Invasiveness 34 III. Cell Motility 40 IV. Motility in Tumor Invasion 76 V. Therapeutic Interventions 83 VI. Summary and Future Directions 89 References 90 Nonenzymatic Interactions between Proteinases and the Cell Surface: Novel Roles in Normal and Malignant Cell Physiology Paolo Mignatti a n d Daniel B. Rifkin I. Introduction 103 II. Extracellular Matrix-Degrading Proteinases: Classification and Structural Features 104 III. Proteolysis-Independent Roles of Extracellular Matrix-Degrading Proteinases 124 IV. Conclusions and Perspectives 143 References 146 V vi Contents Molecular Pathogenesis of AIDS-Associated Kaposi's Sarcoma: Growth and Apoptosis Kaoru Murakami-Mori, Shunsuke Mori, and Benjamin Bohavida I. Introduction 160 11. Histopathogenesis 161 111. Clinical Features 163 N. In Vitro and in Vivo Model