Advances In Molecular And Cellular Endocrinology

ADVANCES IN MOLECULAR AND CELLULAR ENDOCRINOLOGY Volume 2 91998 This Page Intentionally Left Blank ADVANCES IN MOLECU LAR AN D CELLULAR ENDOCRINOLOGY Editor: DEREK LEROITH Diabetes Branch NIDDK National Institutes of Health Bethesda, Maryland VOLUME 2 * 1998 @ Greenwich, Connecticut JA! PRESS INC. London, England Copyright 91998 JA! PRESSINC. 55 Old Post Road No. 2 Greenwich, Connecticut 06836 JAI PRESSLTD. 38 Tavistock Street Covent Garden London WC2E 7PB England All rights reserved. No part of this publication may be reproduced, stored on a retrieval system, or transmitted in any way, or by any means, electronic, mechanical, photocopying, recording, filming or otherwise without prior permission in writing from the publisher. ISBN: 0-7623-0292-5 Manufactured in the United States of America CONTENTS List of Contributors vii Preface Derek LeRoith Chapter 1 MOLECULAR ASPECTS OF PROLACTIN AND GROWTH HORMONE RECEPTORS Vincent Goffin, Fatima Ferrag, and Paul A. Kelly Chapter 2 MOLECULAR ASPECTS OF GROWTH HORMONE ACTION Michael J. Thomas and Peter Rotwein 35 Chapter 3 LEPTIN Marc Reitman 59 Chapter 4 CELLULAR MECHANISMS OF SIGNAL TRANSDUCTION FOR GROWTH FACTORS Alan R. 5altiel 83 Chapter 5 TISSUE-SPECIFIC EXPRESSION OF THE CYP19 (AROMATASE) GENE Evan R. Simpson, M. Dodson Michael, Veena R. Agarwal, Margaret M. Hinshelwood, 5erdar E. Bulun, and Ying Zhao 99 Chapter 6 MOLECULAR ASPECTS OF PRECOCIOUS PUBERTY Wai-Yee Chan and Gordon B. Cutler, Jr. 121 vi CONTENTS Chapter 7 TWO GENES~ONE DISEASE: THE MOLECULAR BASIS OF CONGENITAL NEPHROGENIC DIABETES INSIPIDUS Walter Rosenthal, Alexander Oksche, and Daniel G. Bichet 143 Chapter 8 MECHANISMS OF RADIATION-INDUCED CARCINOGENESIS; THE THYROID MODEL Yuri E. Nikiforov and James A. Fagin INDEX 169 197 LIST OF CONTRIBUTORS Veena R. Agarwal The Cecil H. and Ida Green Center for Reproductive Biology Sciences University of Texas Southwestern Medical Center Dallas, Texas Daniel G. Bichet Department of Medicine University of Montr6al and Service de Nephrologie Montr6al, Qu6bec, Canada Serdar E. Bulun The Cecil H. and Ida Green Center for Reproductive Biology Sciences University of Texas Southwestern Medical Center Dallas, Texas Wai-Yee Chan Department of Pediatrics Georgetown University, Children's Medical Center Washington, DC Gordon B. Cutler, Jr. National Institute of Child Health and Human Development National Institutes of Health Bethesda, Maryland James A. Fagin Division of Endocrinology and Metabolism University of Cincinnati College of Medicine Cincinnati, Ohio vii viii LIST OF CONTRIBUTORS Fatima Ferrag INSERM Unit 344 Molecular Endocrinology Paris, France Vincent Goffin INSERM Unit 344 Molecular Endocrinology Paris, France Margaret M. Hinshelwood The Cecil H. and Ida Green Center for Reproductive Biology Sciences University of Texas Southwestern Medical Center Dallas, Texas Paul A. Kelly INSERM Unit 344 Molecular Endocrinology Paris, France M. Dodson Michael The Cecil H.