Pathological Pain: From Molecular To Clinical Aspects

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This book brings together contributions from key investigators in the area of pathological pain.  It covers the molecular basis of receptors and channels involved in nociception, the possible messages that cause neuropathic plasticity, spinal plasticity in neuropathy, plastic changes in opioid systems in neuropathy and opioid tolerance, and plastic changes related to pathological pain.

 


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PATHOLOGICAL PAIN: FROM MOLECULAR TO CLINICAL ASPECTS The Novartis Foundation is an international scienti¢c and educational charity (UK Registered Charity No. 313574). Known until September 1997 as the Ciba Foundation, it was established in 1947 by the CIBA company of Basle, which merged with Sandoz in 1996, to form Novartis. The Foundation operates independently in London under English trust law. It was formally opened on 22 June 1949. The Foundation promotes the study and general knowledge of science and in particular encourages international co-operation in scienti¢c research. To this end, it organizes internationally acclaimed meetings (typically eight symposia and allied open meetings and 15^20 discussion meetings each year) and publishes eight books per year featuring the presented papers and discussions from the symposia. Although primarily an operational rather than a grant-making foundation, it awards bursaries to young scientists to attend the symposia and afterwards work with one of the other participants. The Foundation’s headquarters at 41 Portland Place, London W1B 1BN, provide library facilities, open to graduates in science and allied disciplines. Media relations are fostered by regular press conferences and by articles prepared by the Foundation’s Science Writer in Residence. The Foundation o¡ers accommodation and meeting facilities to visiting scientists and their societies. Information on all Foundation activities can be found at http://www.novartisfound.org.uk The Novartis (formerly Ciba-Geigy) Foundation (Japan) for the Promotion of Science was established in 1987 under the authorization of the Ministry of Education, Science and Culture as part of the continuing commitment by Ciba-Geigy (now Novartis) AG, Basel, Switzerland, to contribute to human welfare. The Foundation’s mission is to fund innovative research in Japan and support international research meetings in the hope that this will promote the development of the core, scienti¢c technologies necessary for the betterment of the human condition. Information on the Foundation can be found at http://www.novartisfoundation.jp Novartis Foundation Symposium 261 PATHOLOGICAL PAIN: FROM MOLECULAR TO CLINICAL ASPECTS 2004 Copyright & Novartis Foundation 2004 Published in 2004 by John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester PO19 8SQ, UK 01243 779777 National International (+44) 1243 779777 e-mail (for orders and customer service enquiries): [email protected] Visit our Home Page on http://www.wileyeurope.com or http://www.wiley.com All Rights Reserved. No part of this book may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except under the terms of the Copyright, Designs and Patents Act 1988 or under the terms of a licence issued by the Copyright Licensing Agency Ltd, 90 Tottenham Court Road, London W1T 4LP, UK, without the permission in writing of the Publisher. Requests to the Publisher should be addressed to the Permissions Department, John Wiley & Sons Ltd,The Atrium, Southern Gate, Chichester,West Sussex PO19 8SQ, England, or emailed to